NF-kB : a network hub controlling immunity, inflammation, and cancer : a subject collection from Cold Spring Harbor perspectives in biology
著者
書誌事項
NF-kB : a network hub controlling immunity, inflammation, and cancer : a subject collection from Cold Spring Harbor perspectives in biology
（Cold spring harbor perspectives in biology）
Cold Spring Harbor Laboratory Press, c2010
- : hardcover : alk. paper
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-?B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.
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