Tocotrienols : vitamin E beyond tocopherols

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Tocotrienols : vitamin E beyond tocopherols

edited by Ronald Ross Watson, Victor R. Preedy

CRC Press , AOCS Press, c2009

  • : hbk

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Includes bibliographical references and index

Description and Table of Contents

Description

A New Avenue of Research Beyond Traditional Studies of Vitamin E In the current literature, more than 95% of all studies of vitamin E are directed toward the specific exploration of the bioactive component -tocopherol. Until recently, there has been a dearth of research into non-tocopherol vitamin E molecules. A unique resource that examines the newest developments in this area, Tocotrienols: Vitamin E Beyond Tocopherols focuses on the lesser-known vitamin E compound known as tocotrienol. Explores Treatment Possibilities Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book builds upon a recent symposium sponsored by the American Oil Chemists Society. It begins with an overview of tocotrienols, and then examines their sources, chemistry and mechanisms of action. Contributors discuss the uses of tocotrienols in the prevention and treatment of cancer and heart disease, their metabolism and absorption and their potential in the treatment of infectious disease and neurodegeneration, as well as their use as a countermeasure against radiological threat. For the past 10 years, Professors Ronald R. Watson and Victor R. Preedy have published books on bioactive nutrients and dietary supplements. Professor Watson has been and is currently funded to do research by grants from the American Heart Foundation and the U.S. National Institute of Heart, Lung, and Blood. By gathering the contributions contained in this volume, they have expanded the field of knowledge and forged a new path in disease treatment and prevention.

Table of Contents

Introduction and Overview Tocotrienols: A Review, A.G. Schauss Tocotrienols in Vitamin E: Hype or Science?, N.E. Levin and D.L. Clouatre Sources Tocotrienols: Distribution and Sources Cereals-Role in Human Health, H. Zielinski Tocotrienols in Plants: Sources and Importance, L. Harinantenaina Vitamin E: Natural vs. Synthetic, A. Kosowski and D.L. Clouatre Chemistry of Tocotrienols Angiogenesis Inhibition, K. Nakagawa, A. Shibata, P. Sookwong and T. Miyazawa Chemistry of Tocotrienols, S.P. Ghosh, M. Hauer-Jensen, and K.S. Kumar Mechanisms of Action Antioxidant Activity of Tocotrienols in Cells and Serum, R. Simone and P. Palozza Antioxidant Action of Tocotrienols and Tocopherols in Solution and Membranes: Chemical and Physical Effects, Y. Yoshida and E. Niki Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells, P.W. Sylvester DNA Polymerase Inhibition, Y. Mizushina, H. Yoshida, and T. Miyazawa Tocotrienols in Altering the Expression of Adhesion Molecules, Y. Naito and T. Yoshikawa Uptake, Distribution and Protective Action of Tocotrienols in Cultured Cells, N. Noguchi, Y. Saito and E. Niki Cancer Prevention and Treatment Anticancer Effects of Tocotrienols and Tocopherols Irrespective of Anti-Oxidative Properties, T. Yano and N. Virgona Role of the MevalonatePathway in Tocotrienol-Mediated Tumor Suppression, H. Mo and C.E. Elson Telomerase Inhibition, T. Eitsuka, K. Nakagawa and T. Miyazawa Heart Disease Tocopherol and Tocotrienols: Role in Heart Disease Care and Prevention, V. Juturu Tocotrienols and the Regulation of Cholesterol Biosynthesis, J. Cao, W. Qi and B.-L. Song Tocotrienols in Cardiometabolic Diseases, B. Tan and A.M. Mueller Tocotrienols in Hyperlipidemic Conditions, J. Iqba1 and M. Minhajuddin Vitamin E Isomers, Tocotrienols, in Cardioprotection, S. Das, M. Das and D.K. Das Metabolism and Absorption Absorption and Disposition of Tocotrienols, K.-H. Yuen, B.-H. Ng and J.-W. Wong The Metabolism of Tocopherols and Tocotrienols and Novel Functions of Their Metabolites, Q. Jiang Tocotrienols Activate the Steroid and Xenobiotic Receptor SXR to Modulate Small Molecule Metabolism, K.R. Johnson, T. Hsu, and B. Blumberg Health Promotion Tocotrienols in the Potential Treatment of Infectious Disease, A. M. Mueller, B. Tan and E. S. Stuart Tocotrienols as Natural Neuroprotective Vitamins, C.K. Sen, S. Khanna and S. Roy Gamma-Tocotrienol: Potential as a Countermeasure against Radiological Threat, K.S. Kumar, S.P. Ghosh and M. Hauer-Jensen Index

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