Regenerative nephrology
著者
書誌事項
Regenerative nephrology
Academic, c2011
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.
目次
- PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION 1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach Yuko Wakamatsu and Hisashi Hashimoto 2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia Marc R. Hammerman 3. Use of Genetic Mouse Models to study Kidney Regeneration Akio Kobayashi and Jeremy S. Duffield MEDIATORS OF REGENERATION 4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease Charles N. Serhan and Catherine Godson 5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser 6. Mast cells in kidney regeneration Eric Daugas, Walid Beghdadi and Ulrich Blank 7. Role of macrophages in renal injury, repair and regeneration Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris 8. T-cells contribution to regenerative processes Hamid Rabb STEM CELLS IN REGENERATIVE PROCESSES 9. MSC and reparative processes Benjamin D. Humphreys and John V. Bonventre 10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink 11. The potential of the side population in regenerative nephrology Melissa H. Little and G. A. Challen 12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak 13. Stem Cells in Regenerative Processes
- Induced Pluripotent Stem Cells Kenji Osafune and Shinya Yamanaka 14. Methods of Isolation and Culture of Adult Stem cells Lindolfo da Silva Meirelles and Nance Beyer Nardi STEM CELLS - FROM THE NICHE TO REPAIR 15. Stem cell niche in the kidney Laura Lasagni, Elena Lazzeri and Paola Romagnani 16. Creation of artificial niches Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky 17. Imaging of transplanted and native stem cells Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman CAUSES OF REGENERATIVE FAILURE 16. Stem cell injury and premature senescence Michael S. Goligorsky 17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering 18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY 19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data Florian E. Toegel and Christof Westenfelder 20. Clinical trials in Renal Regenerative Medicine Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar 21. Potential risks of stem cell therapies Uta Kunter and Jurgen Floege 22. Tissue engineering in urology Anthony Atala 23. Ethical issues in SC therapy Donald W. Landry 24. Stem Cell Banking Vicente Mirabet and Pilar Solves
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