Nanochromatography and nanocapillary electrophoresis : pharmaceutical and environmental analyses
著者
書誌事項
Nanochromatography and nanocapillary electrophoresis : pharmaceutical and environmental analyses
Wiley, 2009
- : hbk
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Detection of drugs at low concentration is required in a variety of biological and medical situations, in order to avoid harmful side effects posed by some drug residues. The book details the instrumentation, detection, and application of nano chromatography (that is, any chromatographic and capillary electrophoretic method dealing with the detection of a sample at nano gram per liter or lower) and capillary electrophoresis in the analyses of biological and environmental samples. Methods discussed include: Nano Gas Chromatography, Nano Capillary Electrophoresis, Nano Chiral Chromatography, Micellar Electrokinetic Chromatography, Supercritical Fluid Chromatography, and Nano High Performance Liquid Chromatography.
目次
PREFACE xiii
ACKNOWLEDGMENTS xv
1 Introduction 1
1.1. Nanoanalyses 1
1.2. Definition of Nanochromatography and Nanocapillary Electrophoresis 2
1.3. Nanochromatography and Nanocapillary Electrophoresis 3
1.4. Fabrication of Microdevices 4
1.5. Developments in Nanoanalyses 6
1.6. Data Integration 7
1.7. Protocol of Nanoanalyses 10
1.8. Scope of the Book 12
1.9. Conclusion 12
2 Fabrication of Microchips 17
2.1. Introduction 17
2.2. Substrates 18
2.3. Techniques of Fabrication 20
2.4. Surface Modification 39
2.5. Designs of Chips 45
2.6. Bindings in Chips 49
2.7. Conclusion 50
3 Instrumentation of Nanochromatography and Nanocapillary Electrophoresis 59
3.1. Introduction 59
3.2. Nanoliquid Chromatography (NLC) 60
3.3. Nanocapillary Electrophoresis 74
3.4. Conclusion 85
4 Detection in Nanochromatography and Nanocapillary Electrophoresis 91
4.1. Introduction 91
4.2. Mass Spectrometer Detectors 92
4.3. Fluorescence Detectors 97
4.4. Electrochemical Detectors 99
4.5. Element Specific Detectors 101
4.6. Miscellaneous Detectors 103
4.7. Conclusion 105
5 Sample Preparation in Nanochromatography and Nanocapillary Electrophoresis 109
5.1. Introduction 109
5.2. Sample Preparation 111
5.3. Sampling 111
5.4. Preservation 115
5.5. Filtration 116
5.6. Digestion/Homogenization 118
5.7. Extractions 119
5.8. Clean Up 119
5.9. Preconcentration 121
5.10. Off-Line Nanosample Preparation Methods 121
5.11. Online Nanosample Preparation Methods 125
5.12. Conclusion 138
6 Nano-High Performance Liquid Chromatography 145
6.1. Introduction 145
6.2. Nano-HPLC 146
6.3. Applications 146
6.4. Optimization of Separations in Nano-HPLC 161
6.5. Troubleshooting in Nano-HPLC 161
6.6. Conclusion 161
7 Nanocapillary Electrochromatography and Nanomicellar Electrokinetic Chromatography 167
7.1. Introduction 167
7.2. Nanocapillary Electrochromatography 167
7.3. Nanomicellar Electrokinetic Chromatography 181
7.4. Conclusion 188
8 Nanocapillary Electrophoresis 191
8.1. Introduction 191
8.2. Optimization 192
8.3. Applications 200
8.4. Mechanism of Separation 234
8.5. Conclusion 234
9 Chiral Separations by Nanoliquid Chromatography and Nanocapillary Electrophoresis 245
9.1. Introduction 245
9.2. Nanoliquid Chromatography 246
9.3. Nanocapillary Electrophoresis 249
9.4. Mechanisms of Chiral Separation 260
9.5. Conclusion 261
10 Perspectives on Nanoanalyses 263
10.1. Introduction 263
10.2. Future of Microfluidic Devices 264
10.3. Future Challenges 265
10.4. Conclusion 266
References 267
Subject Index 269
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