Systems biomedicine

著者

書誌事項

Systems biomedicine

edited by Edison T. Liu and Douglas A. Lauffenburger

Academic Press, c2010

  • : hbk

タイトル別名

Systems biomedicine : concepts and perspectives

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon.

目次

I. Foundations of Systems Biology Genomic Technologies for Systems Biology Proteomic Technologies II. Computational Modeling of Biological Systems Dynamic Systems Analysis Spatio-temoral Modeling of Cellular Systems High-level modeling of biological networks High-Performance Computing Modeling Software III. Network Biology Protein Interaction Networks Signaling Networks with Modeling Strategies Protein networks in integrin-mediated adhesions Network Imaging RNAi networks IV. Integrative Biology of Higher Biosystems Signal Processing and Integration During Development Systems Biology and Stem Cell Biology Application of immunologic modeling in drug discovery and development V. Systems Medicine Applications Systems Pharmacology

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