Sex chromosomes : genetics, abnormalities and disorders

著者

    • Weingarten, Cynthia N.
    • Jefferson, Sally E.

書誌事項

Sex chromosomes : genetics, abnormalities and disorders

Cynthia N. Weingarten and Sally E. Jefferson, editors

（Genetics - research and issues series）

Nova Biomedical Books, c2009

  • hardcover

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注記

Includes bibliographical references and index

収録内容

  • Sex chromosomes and the genetics of gender differences / A.M. Lopes ... [et al.]
  • Is there always the agreement of chromosomal and phenotypic sex? / Lidka Lisá and Jirí Lisý
  • Genomic imprinting, X chromosome inactivation and gestational trophoblastic diseases / Pei Hui
  • Insights into mammalian X-linked gene function from X-monosomy and X-polysomy / William Davies
  • The fertile XY females of akodon (Rodentia, Sigmodontinae) : the case of A. azarae and A. boliviensis / J.A. Lisanti ... [et al.]
  • Preimplantation diagnosis for aneuploidy screening : a new era beyond FISH / Pere Mir, Julio Martín, and Carmen Rubio
  • The W chromosome evolution and sex-linked gene expression in the Japanese frog Rana rugosa / Ikuo Miura ... [et al.]
  • The Y chromosome of Drosophila melanogaster and the enigma of "functional heterochromatin" / Roberto Piergentili
  • XY male pseudohermaphroditism / R. Payan-Carreira, M.A. Pires, and J. Robalo Silva
  • Genetics and epigenetics variation in the sex chromosomes and their impact on morphological changes and parapatric speciation : species of the genus Mepraia in Chile (Hemiptera : Reduviidae) : a case study / Daniel L. Frías
  • Compensation contemplation / James A. Birchler
  • Dosage compensation : from mice to humans to birds and back again / Ester Silveira Ramos and Susana M. Chuva de Sousa Lopes

内容説明・目次

内容説明

Sex chromosomes determine the sex of an organism. A human somatic cell has two sex chromosomes: XY in male and XX in female. A human germ cell has one sex chromosome: X or Y in a sperm and X in an egg. When an X-sperm is combined with an egg, the resulting zygote (fertilised egg) will contain two X chromosomes. A person developed from the XX-zygote will have the characteristics of a female. Combination of a Y-sperm and an egg will produce a male. Usually, a woman has two X chromosomes (XX) and a man one X and one Y (XY). However, both male and female characteristics can sometimes be found in one individual, and it is possible to have XY women and XX men. Analysis of such individuals has revealed some of the molecules involved in sex determination, including one called SRY, which is important for testis formation. SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape. This alters the properties of the DNA and likely alters the expression of a number of genes, leading to testis formation. Most XX men who lack a Y chromosome do still have a copy of the SRY gene on one of their X chromosomes (moved there by chromosomal translocation). This copy accounts for their maleness. However, because the remainder of the Y chromosome is missing they frequently do not develop secondary sexual characteristics in the usual way. This book presents the latest research in the field from around the world.

目次

  • Preface
  • Sex Chromosomes, Gender Differences and Disease
  • Is There Always the Agreement of Chromosomal and Phenotypic Sex?
  • Genomic Imprinting, X Chromosome Inactivation and Gestational Trophoblastic Diseases
  • Insights into Mammalian X-linked Gene Function From X-Monosomy and X-Polysomy
  • The Fertile xy Females of Akodon (rodentia, sigmodontinae). The Case of a. Azarae and a. Boliviensis
  • Preimplantation Diagnosis For Aneuploidy Screening: A New Era Beyond Fish
  • The W Chromosome Evolution and Sex-linked Gene Expression in the Japanese Frog Rana Rugosa
  • The Y Chromosome of Drosophila Melanogaster and The Enigma of Functional Heterochromatin'
  • XY Male Pseudohermaphroditism
  • Genetics And Epigenetics Variation In The Sex Chromosomes And Their Impact On Morphological Changes And Parapatric Speciation: Species of the Genus Mepraia in Chile
  • Compensation Contemplation
  • Dosage Compensation: From Mice to Humans to Birds and Back Again
  • Index.

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