Protein engineering and design
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Bibliographic Information
Protein engineering and design
CRC Press, c2010
- : hardcover
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science.
Experimental Protein Engineering
The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering.
Computational Protein Design
The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.
Table of Contents
Phage Display Systems for Protein Engineering. Cell Surface Display Systems for Protein Engineering. Cell-Free Display Systems for Protein Engineering. Library Construction for Protein Engineering. Design and Engineering of Synthetic Binding Proteins Using Nonantibody Scaffolds. Combinatorial Enzyme Engineering. Engineering of Therapeutic Proteins. Protein Engineered Biomaterials. Protein Engineering Using Noncanonical Amino Acids. Computer Graphics, Homology Modeling, and Bioinformatics. Knowledge-Based Protein Design. Molecular Force Fields. Rotamer Libraries for Molecular Modeling and Design of Proteins. Search Algorithms. Modulating Protein Structure. Modulation of Intrinsic Properties by Computational Design. Modulating Protein Interactions by Rational and Computational Design. Future Challenges of Computational Protein Design.
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