Insulin receptor substrate signaling in the central nervous system
著者
書誌事項
Insulin receptor substrate signaling in the central nervous system
（Protein science and engineering series）
Nova Science Publishers, 2010
- : pbk
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注記
Includes bibliographical references (p. [37]-58) and index
内容説明・目次
内容説明
Recent advance in molecular biology revealed new insights into the function of insulin receptor signalling and insulin receptor substrate (IRS) protein mediated signals in the central nervous system (CNS) in vivo. The IRS proteins mediate mainly intracellular effects of the insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor (IR). The functions of IRS proteins in peripheral tissues like muscle, liver, pancreas and fat have been characterised in detail. This book examines why IRS signalling is not only critical during brain development, but also for reproduction, energy homeostasis, ageing and possibly for neurodegenerative diseases in humans.
目次
- Introduction
- IRS & IRS-like protein signal transduction
- IRS & IRS-like protein receptors
- Peripheral functions of IRS & IRS-like proteins
- IRS signaling system in the CNS
- IRS signaling in pre-and postnatal brain development
- IRS signaling in CNS disease
- IRS signaling in metabolism & energy homeostasis
- IRS signaling & fertility
- IRS signaling in aging
- Conclusion
- Index.
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