Osteoimmunology : interactions of the immune and skeletal systems


    • Lorenzo, Joseph
    • Choi, Yongwon
    • Horowitz, Mrak
    • Takayanagi, Hiroshi


Osteoimmunology : interactions of the immune and skeletal systems

edited by Joseph Lorenzo ... [et al.]

Academic Press, an imprint of Elsevier, 2011

大学図書館所蔵 件 / 5



Other editors: Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi

Includes bibliographical references and index



Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.


Chapter 1 Overview: The developing Field of Osteoimmunology Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo Chapter 2 The Origins of Bone Cells: Osteoclasts G. David Roodman, Deborah L. Galson Chapter 3 Adaptive Immune Response David G. Hesslein, Hector L. Aguila, Mark C. Horowitz Chapter 4 The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche Henry Kronenberg, Joy Wu Chapter 5 The Signaling Pathways Regulating Osteoblast Differentiation Jane Lian, Gary Stein Chapter 6 The Signaling Pathways Regulating Osteoclast Differentiation Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi Chapter 7 The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells Joseph Lorenzo Chapter 8 Interactions of Osteoblasts and Osteoclasts T. John Martin, Natalie A. Sims, Julian M. W. Quinn Chapter 9 The Role of the Immune System in the Development of Osteoporosis Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder Chapter 10 The Role of the Immune System in the Bone Loss of Inflammatory Arthritis Georg Schett, Steven Goldring Chapter 11 The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease Francisco Sylvester, Anthony T. Vella Chapter 12 The Role of the Immune System in Fracture Healing Louis Gerstenfeld, Thomas Einhorn, Brandon Steen Chapter 13 The Role of the Immune System in the Development of Chronic Infections of Bone Brendan Boyce, Edward Schwarz, Lianping Xing Chapter 14 The Role of the Immune System in Hematologic Malignancies, which Affect Bone Gregory Mundy, Claire M. Edwards, Jessica Fowler Chapter 15 The Role of the Immune System in Dental Disease Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet

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  • ISBN
    • 9780123756701
  • 出版国コード
  • タイトル言語コード
  • 本文言語コード
  • 出版地
    Amsterdam ; Tokyo
  • ページ数/冊数
    xiii, 453 p., [20] p. of plates.
  • 大きさ
    25 cm
  • 分類
  • 件名