DNA microarrays and gene expression : from experiments to data analysis and modeling

Bibliographic Information

DNA microarrays and gene expression : from experiments to data analysis and modeling

Pierre Baldi and G. Wesley Hatfield

Cambridge University Press, 2011

  • :pb

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Includes bibliographical references and index

Description and Table of Contents

Description

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.

Table of Contents

  • Preface
  • 1. A brief history of genomics
  • 2. DNA array formats
  • 3. DNA array readout methods
  • 4. Gene expression profiling experiments: problems, pitfalls and solutions
  • 5. Statistical analysis of array data: inferring changes
  • 6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions
  • 7. Survey of current DNA array applications
  • 8. Systems biology: overview of regulatory, metabolic and signaling networks.

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Details
  • NCID
    BB05675490
  • ISBN
    • 9780521176354
  • LCCN
    2000152862
  • Country Code
    uk
  • Title Language Code
    eng
  • Text Language Code
    eng
  • Place of Publication
    Cambridge
  • Pages/Volumes
    xvi, 213 p.
  • Size
    24 cm
  • Classification
  • Subject Headings
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