Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors
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Bibliographic Information
Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors
（International review of neurobiology, v. 95）
Elsevier Academic Press, c2010
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.
Table of Contents
Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition
Erkki Nissinen
The catechol-O-methyltransferase gene, its regulation and polymorphisms
Elizabeth M. Tunbridge
Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?
Timo T. Myoehanen & Pekka T. Mannistoe
Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms
Thomas Muller
Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors
Erkki Nissinen and Pekka T. Mannistoe
The Chemistry of Catechol-O-methyltransferase Inhibitors
David A. Learmonth, Laszlo E. Kiss and Patricio Soares-da-Silva
Toxicology and safety of COMT inhibitors
Kristiina Haasio
Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment
Concepcio Marin, J.A. Obeso
Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease
Seppo Kaakkola
Catechol-O-methyltransferase and pain
Oleg Kambur & Pekka T. Mannistoe
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