Histamine in inflammation

著者

    • Thurmond, Robin L. (Robin LeRoy)

書誌事項

Histamine in inflammation

edited by Robin L. Thurmond

（Advances in experimental medicine and biology, v. 709）

Springer Science+Business Media , Landes Bioscience, c2010

大学図書館所蔵 件 / 全2件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

収録内容

  • One hundred years of histamine research / Katherine Figueroa and Nigel Shankley
  • Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs
  • Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu
  • Abstract
  • Histamine in allergic rhinitis / Thomas Taylor-Clark
  • The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.]
  • The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate
  • Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer
  • Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff
  • Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy
  • Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula
  • Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas
  • The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond

内容説明・目次

内容説明

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term "antihistamine" has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area-inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

目次

1. One Hundred Years of Histamine Research Katherine Figueroa and Nigel ShankleyAbstractIntroductionExploring the Physiological Effects of HistamineThe First AntihistaminesPharmacological Definition of Histamine H1 and H2 ReceptorsPharmacological Definition of the Histamine H3 ReceptorPharmacological Definition of the Histamine H4 ReceptorThe Molecular Biological Characterization of Histamine ReceptorsAlternative Intracellular Signaling of Histamine ReceptorsGenerations of Histamine Targeted Genetically Modified MiceConclusion2. Molecular Pharmacology of the Four Histamine ReceptorsGerold Bongers, Iwan de Esch and Rob LeursAbstractThe Discovery of the Four Histamine Receptors: An Historical OverviewHistamine Receptors, Signal Transduction and Their LigandsThe Histamine H1 Receptor and Its LigandsThe Histamine H2 Receptor and Its LigandsThe Histamine H3 Receptor and Its LigandsThe Histamine H4 Receptor and Its LigandsConclusion3. Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient MiceHiroshi OhtsuAbstractIntroductionHDC Transcriptional RegulationEpigenetic Regulation of HDC Gene Expressionl?Histidine Decarboxylase Gene Knockout MiceHistamine and ImmunityHistamine in Wound HealingHistamine in MalariaHistamine in Crohn'sDiseaseHistamine in Allergic Bronchial AsthmaHistamine in Systemic Anaphylaxis ModelHistamine in AtherosclerosisHistamine Uptake into and Release from Histamine Producing CellsConclusion4. Histamine in Allergic Rhinitis Thomas Taylor?ClarkAbstractIntroductionHistamine and the Early Phase Response in Allergic RhinitisH1 Receptors: Sensory Nerve Activation and Central ReflexesH1 Receptors and the Nasal VasculatureOther Histamine Receptors in the Early Phase ResponseHistamine Receptors and Immune ModulationConclusion5. The Role of Histamine in Ocular Allergy Masaharu Ohbayashi, Bita Manzouri, Kei Morohoshi, Ken Fukuda and Santa J.OnoAbstractIntroductionClinical Manifestations of Ocular AllergyCurrent Treatments for Ocular AllergyAllergic Responses in the ConjunctivaMast Cells in the ConjunctivaHistamine in the ConjunctivaHistamine and the Conjunctival BarrierHistamine Receptors in the ConjunctivaTissue?Specific Roles of Histamine ReceptorsConclusion6. The Role of Histamine in Asthma Paul J. Dunford and Stephen T. HolgateAbstractIntroductionHistamine in the Asthmatic AirwayPhysiologic Role for Histamine in Lung and AsthmaImmunological Modulation by

「Nielsen BookData」 より

関連文献： 1件中  1-1を表示

詳細情報

ページトップへ