Microarray methods for drug discovery
著者
書誌事項
Microarray methods for drug discovery
(Methods in molecular biology / John M. Walker, series editor, 632)(Springer protocols)
Humana Press, c2010
- : cased
- : e-book
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The postgenomic era presents a multitude of challenges for scientists in all areas of science. The information overload from new discoveries in genomics and proteomics highlight how little we really know about the functioning of a cell. The advent of Next-Generation Sequencing technologies promises to make our genetic blueprint available to the common man. The availability of the plethora of biological information has lead to the devel- ment of new areas of science and the coining of new "omics" terms including transcr- tomics, methylomics, toxicogenomics, pharmacogenomics, metabolomics, lipidomics, and so on. Remarkable research is being conducted to understand the various aspects of human health and how processes like histone modifcations, promoter usage, alternative splicing, posttranscriptional, and posttranslational modifcations contribute to disease. The advent of systems biology has unifed chemists and biochemists alike in the struggle to eradicate or treat human disease. Microarrays have blossomed into a fast developing and cutting-edge technology that promises to become a major component of personalized medicine.
The 1990s witnessed a boom in many areas including genome sequencing, combinatorial chemistry, and c- puters, all of which have contributed to the development of microarray technology from its infancy into a mature tool. The growing potential of this tool is evident from the n- ber of publications since 1991 when Fodor et al. of Affymax (now Affymetrix) frst described the microarray prototype.
目次
1. Multicenter Clinical Sample Collection for Microarray Analysis
Tony S. Mondala, Daniel R. Salomon, and Steven R. Head
2. Selective Isolation of Total RNA from Mouse Melanoma Subsets Using Fluorescence Activated Cell Sorting
Scott Tighe and Matthew A. Held
3. Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid Bodies
Alexander C. Zambon and Christopher S. Barker
4. Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST Arrays
Sita Subbaram, Marcy Kuentzel, David Frank, C. Michael DiPersio, and Sridar V. Chittur
5. Profiling microRNA Expression with the Illumina BeadChip Platform
Julissa Tsao, Patrick Yau, and Neil Winegarden
6. TaqMan (R) Array Cards in Pharmaceutical Research
David N. Keys, Janice K. Au-Young, and Richard A. Fekete
7. DMET (TM) Microarray Technology for Pharmacogenomics-Based Personalized Medicine
James K. Burmester, Marina Sedova, Michael H. Shapero, and Elaine Mansfield
8. The Use of Microarray Technology for Cytogenetics
Bassem A. Bejjani, Lisa G. Shaffer, and Blake C. Ballif
9. PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious Disease
Maneesh Pingle, Mark Rundell, Sanchita Das, Linnie M. Golightly, and Francis Barany
10. RIP-CHIP in Drug Development
Ritu Jain, Francis Doyle, Ajish D. George, Marcy Kuentzel, David Frank, Sridar V. Chittur, and Scott A. Tenenbaum
11. ChIPing Away At Global Transcriptional Regulation
Kelly Jackson, James Paris, and Mark Takahashi
12. HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B Lymphocytes
Rita Shaknovich, Maria E. Figueroa, and Ari Melnick
13. High-Throughput Screening of Metalloproteases Using SmallMolecule Microarrays
Mahesh Uttamchandani
14. Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity Screening
Moo-Yeal Lee, Jonathan S. Dordick, and Douglas S. Clark
15. Use of Tissue Microarray to Facilitate Oncology Research
Panagiotis Gouveris, Paul M. Weinberger, and Amanda Psyrri
16. Small Molecule Selectivity and Specificity Profiling Using Functional Protein Microarrays
Peter R. Kraus, Lihao Meng, and Lisa Freeman-Cook
17. Production and Application of Glycan Microarrays
Julia Busch, Ryan McBride, and Steven R. Head
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