Monolithic chromatography and its modern applications
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Bibliographic Information
Monolithic chromatography and its modern applications
（Chromsoc separation science series）
ILM, 2010
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Includes bibliographical references and index
Description and Table of Contents
Description
High-performance liquid chromatography has become the predominant global separation technique over the past four decades. However, the recent development of an alternative column packing material - a one-piece porous solid known as a 'monolith' - has transformed the field. Monoliths have attracted a large amount of interest due to the enhanced speed and thoroughness with which they can separate complex mixtures of biological molecules. Monoliths are porous rod structures characterised by mesopores and macropores. These pores provide monoliths with high permeability, a large number of channels and a high surface area available for reactivity. The backbone of a monolithic column is composed of either an organic or inorganic substrate and can easily be chemically altered for specific applications. Their unique structure gives them several physico-mechanical properties that enable them to perform competitively against traditionally packed columns. In this book, which is endorsed by ChromSoc and EuSSS, global experts comprehensively describe this developing field. Part I covers the synthesis and characterisation of the columns and Part II dicusses their numerous applications.
This volume will be of interest to those already using monolithic columns, as well as those who are new to the area and would like to know more about this technique.
Table of Contents
Part I Synthesis and Characterisation of Monolithic Columns Chapter 1 Affinity Monolith Chromatography: Principles and Recent Developments (Michelle J. Yoo and David S. Hage) Chapter 2 Characterisation of Pore Structure and Its Impact on the Chromatographic Properties of Organic Polymer Monolithic Capillary Columns (Pavel Jandera and Jiri Urban) Chapter 3 Silica-based Porous Monoliths: Synthesis, Characterisation and Applications in Chromatographic Separation (Hua Zhong and Qihua Yang) Chapter 4 Preparation and Characterisation of Organic Polymer Monolithic Capillary Columns (Pavel Coufal, Zuzana Bosakova, Jakub Sirc, Vera Pacakova and Karel Stulik) Chapter 5 Ring-opening Metathesis Polymerisation- derived Capillary Monoliths: Versatile Analytical Tools for Modern Biomedical Research (Frank M. Sinner and Christina Gatschelhofer) Chapter 6 Monolithic Cryogel Beds Prepared Under Varying Freezing Temperatures and Their Application in the Isolation of Nucleotides (Kejian Yao, Junxian Yun and Shaochuan Shen) Chapter 7 Organic Monoliths as Stationary Phases in Chromatography (Andreas Greiderer, S. Clark Ligon Jr., Christian W. Huck and Gunther K. Bonn) Part II Applications of Monolithic Columns Chapter 8 Applications of Monolithic Chromatography in Pharmaceutical Analysis (Debby Mangelings and Yvan Vander Heyden) Chapter 9 Monolithic Columns in Microscale Separations (Ren'an Wu and Hanfa Zou) Chapter 10 Monolithic Ion Exchange Phases for the Separation of Small Inorganic and Organic Ions (Brett Paull and Damian Connolly) Chapter 11 Monolithic Column Chromatography Coupled with Chemiluminescence Detection (Paul S. Francis and Jacqui L. Adcock) Chapter 12 Fast Separations of Phytochemicals by High-performance Liquid Chromatography Using Monolithic Columns (Mauricio A. Rostagno and Ana Villares) Chapter 13 Monolithic Stationary Phases for Affinity-based Separations (Panagiotis Manesiotis and Georgios Theodoridis) Chapter 14 Immobilisation of Enzymes on Monolithic Matrices: Applications in Drug Discovery (Vincenza Andrisano and Manuela Bartolini) Chapter 15 Applications of Monolithic Chromatography in Support of Pharmaceutical Development of Drug Substances and Formulations (Naijun Wu and Zhong Li) Chapter 16 Use of Monolithic Material as On-line Extraction Support for High-throughput Liquid Chromatography Tandem Mass Spectrometry Analysis of Biological Samples (Raymond Naxing Xu, Grace E. Kim, Maria P. Metchkarova, Phillip Vaca, Matthew J. Rieser and Tawakol A. El-Shourbagy) Chapter 17 Convective Interaction Media Monoliths for Separation and Purification of pDNA and Viruses (Matjaz Peterka, Petra Kramberger and Ales Strancar) Chapter 18 Analysis of Methylated Arginines and Amino Acids Using a Monolithic Silica Column (Makoto Tsunoda) Chapter 19 Applications of Monolithic Columns in the Analysis of Illicit Drug Samples (Kim McFadden and Brian Carney) Chapter 20 Applications of Monolithic Phases in Fundamental Studies of Vegetable Proteins and Food Analysis and Technology (J.M. Saz and M.L. Marina) Chapter 21 Toxicological Analysis Using Monolithic Silica Spin-column Extraction and Chromatographic Separations (Takeshi Saito, Akira Namera and Akihiro Nakamoto) Chapter 22 Amphiphilic Acrylamide-based Continuous Beds in Capillary Electrochromatography (Olga Kornysova, Audrius Maruska and Ute Pyell) Index
by "Nielsen BookData"
