Structural biology of DNA damage and repair

著者

    • Stone, Michael P.

書誌事項

Structural biology of DNA damage and repair

Michael P. Stone, editor

（ACS symposium series, 1041）

American Chemical Society, c2010

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications. The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair.

目次

  • PREFACE
  • MICHAEL P. STONE
  • KYLE L. BROWN, MARINA ROGINSKAYA, YUE ZOU, ALVIN ALTAMIRANO, ASHIS K. BASU, AND MICHAEL P. STONE
  • EMILY H. RUBINSON, SURAJ ADHIKARY, AND BRANDT F. EICHMAN
  • JOSHUA I. FRIEDMAN AND JAMES T. STIVERS
  • STEVEN M. SHELL AND WALTER J. CHAZIN
  • REBECCA GUZA, ANTHONY E. PEGG, AND NATALIA TRETYAKOVA
  • ELIZAVETA S. GROMOVA, OKSANA M. SUBACH, VLADIMIR B. BASKUNOV, AND NICHOLAS E. GEACINTOV
  • INDEXES
  • AUTHOR INDEX
  • SUBJECT INDEX

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