Chiral drugs : chemistry and biological action

著者

    • Lin, Guo-Qiang
    • You, Qi-Dong
    • Cheng, Jie-Fei

書誌事項

Chiral drugs : chemistry and biological action

edited by Guo-Qiang Lin, Qi-Dong You, Jie-Fei Cheng

Wiley, c2011

大学図書館所蔵 件 / 全4件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.

目次

ABOUT THE EDITORS vii CONTRIBUTORS ix INTRODUCTION 1 1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3 Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng 2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29 Guo-Qiang Lin and Xing-Wen Sun 3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77 Jianqiang Wang and Wenya Lu 4 RESOLUTION OF CHIRAL DRUGS 137 Qi-Dong You 5 FLUORINE-CONTAINING CHIRAL DRUGS 195 Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing 6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253 Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni 7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297 Deping Wang and Eric Hu 8 PHARMACOLOGY OF CHIRAL DRUGS 323 Yongge Liu and Xiao-Hui Gu 9 PHARMACOKINETICS OF CHIRAL DRUGS 347 Hanqing Dong, Xiaochuan Guo and Zengbiao Li 10 TOXICOLOGY OF CHIRAL DRUGS 381 Guang Yang and Hai-Zhi Bu 11 REPRESENTATIVE CHIRAL DRUGS 401 Jiangqin Sun, Dingguo Liu, and Zhimin Wang INDEX 449

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