Cancer metastasis : biologic basis and therapeutics
著者
書誌事項
Cancer metastasis : biologic basis and therapeutics
Cambridge University Press, 2011
- : hbk
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
目次
- Overview: biology is the foundation of therapy
- Part I. Basic Research: Introduction to basic research
- Section 1. Models and Tools for Metastasis Studies: 1. Animal models of cancer metastasis
- 2. Drosophila and zebrafish: genetic models for cancer metastasis
- 3. Computational models
- 4. Intravital microscopy to visualize invasion and metastasis
- Section 2. Genes: 5. Metastasis-promoting genes
- 6. The role of metastasis suppressor genes in metastasis
- 7. Stromal-derived factors that dictate organ-specific metastasis
- 8. Metastasis genes: epigenetics
- 9. Germline variation and other host determinants of metastatic potential
- 10. The influence of aging and cellular senescence on metastasis
- Section 3. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer
- 12. Apoptosis, anoikis, and senescence
- 13. Metastatic inefficiency and tumor dormancy
- Section 4. Stromal Cells/Extracellular Matrix: 14. Role of inflammation in metastatic progression
- 15. Proteolytic cascades in invasion and metastasis
- 16. Role of matrix metalloproteinases in tumor invasion and metastasis
- 17. Cell-derived microvesicles and metastasis
- Section 5. Systemic Factors: 18. Exploring the earliest steps in metastasis: the pre-metastatic niche
- 19. Growth regulatory pathways contributing to organ selectivity of metastasis
- 20. Determinants of organ-specific metastasis
- 21. Function and expression of the uPA/uPAR system in cancer metastasis
- 22. The lymphatics: on the route to cancer metastasis
- Part II. Clinical Research: 23. Introduction to clinical research
- 24. Sarcoma
- 25. Neuroblastoma
- 26. Retinoblastoma
- 27. Primary brain tumors and cerebral metastases
- 28. Head and neck cancer metastasis
- 29. Cutaneous melanoma: therapeutic approaches for metastatic disease
- 30. Gastric cancer metastasis
- 31. Metastatic pancreatic cancer
- 32. Metastasis of primary liver cancer
- 33. Advances in management of metastatic colorectal cancer
- 34. Lung cancer metastasis
- 35. Metastatic thyroid cancer: evaluation and treatment
- 36. Metastatic renal cell carcinoma
- 37. Bladder cancer
- 38. Bone complications of myeloma and lymphoma
- 39. Breast metastasis
- 40. Gynecologic malignancies
- 41. Prostate cancer metastasis: thoughts on biology and therapeutics
- 42. The biology and treatment of metastatic testicular cancer
- 43. Applications of proteomics to metastasis diagnosis and individualized therapy
- 44. Critical issues of research on circulating and disseminated tumor cells in cancer patients
- 45. Lymphatic mapping and sentinel lymph node biopsy
- 46. Molecular imaging and metastasis
- 47. Preserving bone health in malignancy and complications of bone metastases
- 48. Role of platelets and thrombin in metastasis
- Section 6. Therapies: 49. Cancer nanotechnology offers great promise for cancer research and therapy
- 50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials
- 51. Immunotherapy
- 52. Discovery and development of drugs targeting tumor invasion and metastasis
- 53. The role of radiotherapy in the treatment of metastatic disease
- 54. Prospects for clinical trials of metastasis inhibitors.
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