Adenoviral vectors for gene therapy
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Bibliographic Information
Adenoviral vectors for gene therapy
Academic Press, c2002
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Note
Includes bibliographical references
Description and Table of Contents
Description
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.
Table of Contents
Adenovirus Structure
Biology of Adenovirus Cell Entry
Adenovirus Replication
Adenoviral Vector Construction I: Mammalian Systems
Adenoviral Vector Construction II: Bacterial Systems
Propagation of Adenoviral Vectors: Use of PER.C6 Cells
Purification of Adenovirus
Targeted Adenoviral Vectors I: Transductional Targeting
Targeted Adenoviral Vectors II: Transcriptional Targeting
Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer
Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer
Innate Immune Responses to in Vivo Adenovirus Infection
Humoral Immune Response
Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy
High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications
Xenogenic Adenoviral Vectors
Hybrid Adenoviral Vectors
Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer
Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease
Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases
Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations
Imaging Adenovirus-Medicated Gene Transfer
by "Nielsen BookData"