Targeted radionuclide therapy
著者
書誌事項
Targeted radionuclide therapy
Wolters Kluwer Health/Lippincott Williams & Wilkins, c2011
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion.
目次
Part I: IMMUNOLOGY AND TARGETING CONSTRUCTS 1: The Immune System 2: Methods for Development of Monoclonal Antibody Therapeutics 3: Peptides 4: Affibody Molecules for Targeted Radionuclide Therapy 5: Aptamers Part II: PHYSICS AND RADIOBIOLOGY OF TRT 6: The Physics and Radiobiology of TRT 7: Chelation Chemistry 8: Radiation Dosimetry 9: Microdosimetry 10: Radiation Safety for RT Part III: TUMOR MICROENVIRONMENT AND DELIVERY STRATEGIES 11: Employing SEREX 12: Antibody Penetration into Tumors 13: Overcoming Barriers Posed by Solid Tumors 14: The Delivery Construct 15: The Type of Radionuclide 16: Pretargeting Strategies for TRT 17: Combined Modality Strategies 18: Extracorporeal Techniques 19: Concept of Systemic Therapy 20: Modeling of the Systemic Cure with TRT Part IV: UNCONJUGATED THERAPY 21: Thyroid Cancer 22: Unconjugated Radiopharmaceuticals 23: 90-y Microspheres 24: SIRT Part V: CONJUGATED THERAPY 25: Colorectal Cancer 26: Pancreatic Cancer 27: Hepatobillary Cancer 28: Astrocytoma 29: Medullary Thyroid Cancer 30: Head and Neck Cancer 31: Prostate Cancer 32: Renal Cell Carcinoma 33: Bladder Cancer 34: Leukemia 35: Non-Hodgkin's Lymphoma 36: Hodgkin's Disease 37: Multiple Myeloma 38: Neuroendocrine Tumors 39: Malignancies Treated with Peptides 40: Ovarian Cancer 41: Osteosarcoma 42: Pediatric Tumors 43: Palliation 44: Melanoma
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