Unraveling the genetics of bovine Johne's disease

著者

    • Verschoor, Chris P.
    • Pant, Sameer D.
    • Karrow, Niel A.

書誌事項

Unraveling the genetics of bovine Johne's disease

Chris P. Verschoor, Sameer D. Pant, Niel A. Karrow

（Digestive diseases--research and clinical developments）

Nova Science Publishers, 2010

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Johne's disease is a chronic, granulomatous enteritis of ruminants and some wild-type species that is caused by infection with Mycobacterium avium spp. paratuberculosis (MAP). This inflammatory bowel disease (IBD) is characterised by a lengthy yet variable asymptomatic subclinical phase in which infected animals can transmit MAP to their progeny and herd mates; this is followed by a clinical phase characterised by chronic diarrhoea, wasting, and eventually death. The impact of Johne's disease is particularly evident in the dairy and beef industries, where significant losses due to reduced productivity and fertility, mortality, and premature culling have been reported. This book addresses the genetics of this condition and its possible treatments.

目次

  • Introduction
  • MAP & the Bovine Immune Response
  • A Role for CD8+ & ?d-T Cells in Early Infection
  • The Host Response during the sub-clinical phase of infection
  • Clinical phase
  • Pathological similarities between Johne's disease & Crohn's disease
  • A genetic basis for mammalian IBDs
  • Potential susceptibility loci conserved across mammalian IBDs
  • Impact of alternate mechanisms of gene regulation
  • Conclusion
  • Index.

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