The neurobiology of addiction : new vistas
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書誌事項
The neurobiology of addiction : new vistas
Oxford University Press, 2010
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注記
Originating from a theme issue first published in Philosophical transactions of the Royal Society B, Biological sciences, 12 Oct. 2008
Includes bibliographical references and index
内容説明・目次
内容説明
In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved
in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex.
The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs
- alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new
pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology.
The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.
目次
- Introduction. The neurobiology of drug addiction: new vistas
- Neurobiological mechanisms for opponent motivational processes in addiction
- Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
- The incentive sensitization theory of addiction: some current issues
- Psychological and neural mechanisms of relapse
- Neurobiology of nicotine dependence
- Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex
- The neurobiology of pathological gambling and drug addiction: an overview and new findings
- Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
- Neurogenetic studies of alcohol addiction
- Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders
- Positron emission tomography imaging studies of dopamine receptors in primate models of addiction
- Context-induced relapse to drug seeking: a review
- Transcriptional mechanisms of addiction: role of changes in FosB
- Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys
- Acute effects of cocaine on the neurobiology of cognitive control
- Evidence-based treatments of addiction
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