Telomerase : composition, functions and clinical implications
著者
書誌事項
Telomerase : composition, functions and clinical implications
（DNA : properties and modifications, functions and interactions, recombination and applications series）（Nova biomedical）
Nova Science, c2010
- : hbk
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注記
Includes bibliographical references (p. 126-144) and index
内容説明・目次
内容説明
Telomerase is a ribonucleoprotein enzyme that catalyses the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential. Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumour progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.
目次
- Preface
- Telomerase Beyond Telomeres: New Roles for an Old Enzyme
- Telomerase & Telomeric Proteins: A Life Beyond Telomeres
- Histone Deacetylase Inhibition as an Anticancer Telomerase-Targeting Strategy
- Telomerase Role in Pituitary Adenomas
- Regulations of Telomerase Activity & WRN Gene Expression
- Telomerase & Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis
- Index.
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