Intestinal immune system
Author(s)
Bibliographic Information
Intestinal immune system
（Integrated systems physiology : from molecule to function to disease, 25）
Morgan & Claypool Life Sciences, c2011
- : pbk
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Note
Includes bibliographical references (p. 95-110)
Description and Table of Contents
Description
In the intestine, a unique immunological system that is different from the systemic immune system exists to provide adaptive immunity in response to luminal bacteria and dietary antigens. There are many lymphoid cell aggregates called gut-associated lymphoid tissue (GALT) including Peyer's patches (PPs), which function as important induction sites for the mucosal immune response. M-cells are present in the epithelium of PPs, having a specialized structure for uptake of macromolecules such as bacteria. In addition to GALT, there are abundant lymphoid cells in the intestinal lamina propria, where they mainly play a role as immune effector cells. A strong innate immune system that mainly consists of dendritic cells, macrophages, and ??T lymphocytes also exists in the intestinal mucosa to assist the barrier function of intestinal epithelial cells.
The intestinal mucosa thus shows a unique morphological structure with many immune cells being present under physiological conditions. This condition is known as ""controlled inflammation."" These abundant immune cells also have characteristic functions: they are ""negatively regulated"" and have been educated not to overreact unnecessarily to the intestinal luminal milieu. Main players that control inflammation of the intestinal mucosa include regulatory cytokines and regulatory T cells which induce oral tolerance to intestinal bacteria and food antigens, and the secretory IgA system. The maintenance of unique immunological activity in the intestine is also related to an organized, orchestrated lymphocyte migratory mechanism called the ""common mucosal immune system.""
These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, although their exact etiological mechanisms remain to be revealed.
Table of Contents
Introduction
GALT: Its Structure and Formation
Intestinal Epithelial Cells and Their Immune Function
Innate Immunity in the Intestinal Mucosa
Intraepithelial Lymphocytes (IELs)
Lymphoid Cell Trafficking in Intestinal Immunology
Site of Induction of Mucosal Immunity and Antigen Presentation by Dendritic Cells
Production of Secretory IgA (SIgA)
Effector Site of Acquired Immunity and T Helper Cell Subpopulation
Immune Regulatory System and Oral Tolerance
Food Allergy and Celiac Disease
Inflammatory Bowel Diseases
Enteric Infection with Pathogenic Microbes and Mucosal Immunity
References
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