Green chemistry in the pharmaceutical industry

著者

    • Dunn, Peter J. (Peter James)
    • Wells, Andrew S.
    • Williams, Michael T. (Michael Trevelyan)

書誌事項

Green chemistry in the pharmaceutical industry

edited by Peter J. Dunn, Andrew S. Wells, and Michael T. Williams

（Green chemistry）

Wiley-VCH, c2010

大学図書館所蔵 件 / 全3件

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注記

Description based on 2011 printing

Includes bibliographical references and index

収録内容

  • Introduction to green chemistry, organic synthesis and pharmaceuticals / Roger Sheldon
  • Green chemistry metrics / Richard K. Henderson, David J.C. Constable, and Concepción jiménez-González
  • Solvent use and waste issues / C. Stewart Slater ... [et al.]
  • Environmental and regulatory aspects / David Taylor and Vyvyan T. Coombe
  • Synthesis of sitagliptin, the active ingredient in Januvia and Janumet / Jaume Balsells ... [et al.]
  • The development of short, efficient, economic, and sustainable chemoenzymatic processes for statin side chains / Martin Schürmann ... [et al.]
  • The Taxol story-development of a green synthesis via plant cell fermentation / Pia G. Mountford
  • The development of a green, energy efficient, chemoenzymatic manufacturing process for pregabalin / Peter J. Dunn ... [et al.]
  • Green processes for peptide mimetic diabetic drugs / Yasuhiro Sawai and Mitsuhisa Yamano
  • The development of an environmentally sustainable process for radafaxine / Trevor Grinter
  • Continuous processing in the pharmaceutical industry / Lee Proctor ... [et al.]
  • Preparative and industrial scale chromatography : green and integrated processes / Eric Lang ... [et al.]
  • Dynamic resolution of chiral amine pharmaceuticals : turning waste isomers into useful product / John Blacker and Catherine E. Headley
  • Green technologies in the generic pharmaceutical industry / Apurba Bhattacharya and Rakeshwar Bandichhor
  • Environmental considerations in biologics manufacture / Sa V. Ho
  • Future trends for green chemistry in the pharmaceutical industry / Peter J. Dunn, Andrew S. Wells, and Michael T. Williams

内容説明・目次

内容説明

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

目次

INTRODUCTION TO GREEN CHEMISTRY, ORGANIC SYNTHESIS AND PHARMACEUTICALS The Development of Organic Synthesis The Environmental Factor The Role of Catalysis Green Chemistry: Benign by Design Ibuprofen Manufacture The Question of Solvents: Alternative Reaction Media Biocatalysis: Green Chemistry Meets White Biotechnology Conclusions and Prospects GREEN CHEMISTRY METRICS Introduction Measuring Resource Usage Life Cycle Assessment (LCA) Measuring Chemistry and Process Efficiency Measuring Process Parameters and Emissions Real Time Analysis Operational Efficiency Measuring Energy Measuring the Toxicity of All the Substrates Measuring Degradation Potential Measuring the Inherent Safety of Lack of Inherent Safety Conclusions SOLVENT USE AND WASTE ISSUES Introduction to Solvent Use and Waste Issues Solvent and Process Greenness Scoring and Selection Tools Waste Minimization and Solvent Recovery ENVIRONMENTAL AND REGULATORY ASPECTS Historical Perspective Pharmaceuticals in the Environment Environmental Regulations A Look to the Future SYNTHESIS OF SITAGLIPTIN, THE ACTIVE INGREDIENT IN JANUVIA AND JANUMET Introduction First-Generation Route Sitagliptin through Diastereoselective Hydrogenation of an Enamine. The PGA Enamine-Ester Route The Triazole Fragment Direct Preparation of Beta-Keto Amides Second-Generation Chiral Auxiliary Route. The PGA Enamine-Amide Route Prufication and Isolation of Sitagliptin (Pharmaceutical Form) The Final Manufacturing Route THE DEVELOPMENT OF SHORT, EFFICIENT, ECONOMIC, AND SUSTAINABLE CHEMOENZYMATIC PROCESSES FOR STATIN SIDE CHAINS Introduction: Biocatalysis The Relevance of Statins Biocatalytic Routes to Statin Side Chains 2-Deoxy-D-Ribose 5-Phosphate Aldolase (DERA)-Based Routes to Statin Intermediates Conclusions THE TAXOL STORY-DEVELOPMENT OF A GREEN SYNTHESIS VIA PLANT CELL FERMENTATION Introduction Discovery and Early Development From Extraction of Taxol from Pacific Yew Tree Bark to Semi-Synthetic Taxol Taxol from Plant Cell Fermentation Comparison of Semi-Synthetic versus PCF Taxol Processes: The Environmental Impact Comparison of Semi-Synthetic versus PCF Taxol: Green Chemistry Principles Final Words THE DEVELOPMENT OF A GREEN, ENERGY EFFICIENT, CHEMOENZYMATIC MANUFACTURING PROCESS OF PREGABALIN Introduction Process Routes to Pregabalin Biocatalytic Route to Pregabalin Green Chemistry Considerations Conclusions GREEN PROCESSES FOR PEPTIDE MIMETIC DIABETIC DRUGS Introduction Green Chemistry Considerations in Peptide-like API manufacture Purification Process to Manufacture Amorphous API Preparation of Unnatural Amino Acids Summary THE DEVELOPMENT OF AN ENVIRONMENTALLY SUSTAINABLE PROCESS FOR RADAFAXINE Introduction Chemistry Process and the Dynamic Kinetic Resolution (DKR) Multicolumn Chromatography - Development of Route 4 Environmental Assessment Summary CONTINUOUS PROCESSING IN THE PHARMACEUTICAL INDUSTRY Introduction Continuous Production of a Key Intermediate for Atorvastatin Continuous Process to Prepare Celecoxib Continuous Oxidation of Alcohols to Aldehydes Continuous Production of Bromonitromethane Continuous Production and Use of Diazomehtane A Snapshot of Some Further Continuous Processes Used in the Preparation of Pharmaceutical Agents Conclusions PREPARATIVE AND INDUSTRIAL SCALE CHROMATOGRAPHY: GREEN AND INTEGRATED PROCESSES Introduction Basic Principles of Chromatography Process Optimization to Reduce Eluent Consumption Use of a Green Solvent: Supercritical Carbon Dioxide Solvent Recycling Technologies Application Examples Conclusion: An Environmentally Friendly Solution for Each Separation DYNAMIC RESOLUTION OF CHIRAL AMINE PHARMACEUTICALS: TURNING WASTE ISOMERS INTO USEFUL PRODUCT Background Integration of Chiral Amine Resolution and Racemization Case Studies Conclusions GREEN TECHNOLOGIES IN THE GENERIC PHARMACEUTICAL INDUSTRY Introduction 'Waste': Definition and Remedy Amidation Synthesis of Galanthamine Synthesis of Solefinacin Synthesis of Levetiracetam Synthesis of a Finasteride Intermediate Bromination Sulfoxidation in the Synthesis of Rabeprazole Conclusions ENVIRONMENTAL CONSIDERATIONS IN BIOLOGICS MANUFACTURE Introduction Therapeutic Biologics Environmental Impact Considerations Overall Comparison Environmental Indices for Therapeutic Protein Manufacture Technologies with Potential Environmental Impact Single-Use Biologics Manufacture Summary FUTURE TRENDS FOR GREEN CHEMISTRY IN THE PHARMACEUTICAL INDUSTRY Introduction Waste Minimization in Drug Discovery Greener Synthetic Methods in Primary Manufacturing Alternative Solvents in the Pharmaceutical Industry Green Chemistry in Secondary Pharmaceutical Operations Global Cooperation in Green Chemistry Conclusions

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