Monolithic silicas in separation science : concepts, syntheses, characterization, modeling and applications
著者
書誌事項
Monolithic silicas in separation science : concepts, syntheses, characterization, modeling and applications
Wiley-VCH Verlag GmbH, c2011
- : hbk
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Edited by the experts and pioneers in the field, this is the first monograph to cover the topic, containing the must-have information hitherto only scattered among journals.
Clearly divided into sections on preparation, characterization and modeling, and applications, this is essential reading for chemists, chromatographers, analytical chemists, biochemists and biologists.
目次
Preface
THE BASIC IDEA AND THE DRIVERS
Definitions
Monoliths as Heterogeneous Catalysts
Monoliths in Chromatographic Separations
Conclusion and Perspectives
PART I: Preparation
SYNTHESIS CONCEPTS AND PREPARATION OF SILICA MONOLITHS
Introduction
Background and Concepts
Synthesis of Silica Monoliths
Monolithic Columns Prepared in the Laboratory
PREPARATION AND PROPERTIES OF VARIOUS TYPES OF MONOLITHIC SILICA STATIONARY PHASES FOR REVERSED-PHASE, HYDROPHILIC INTERACTION, AND ION-EXCHANGE CHROMATOGRAPHY BASED ON POLYMER-COATED MATERIALS
Stationary Phases for Reversed-Phase Chromatography
Stationary Phases for Hydrophilic-Interaction Chromatography Separations
Stationary Phases for Ion-Exchange Separations
Advantages of Polymer-Coated Monolithic Silica Columns
PART II: Characterization and Modeling
CHARACTERIZATION OF THE PORE STRUCTURE OF MONOLITHIC SILICAS
Monolithic Silicas
General Aspects Describing Porous Materials
Characterization Methods of the Pore Structure of Monolithic Silicas
Comparison of the Silica Monolith Mesopore-Characterization Data
Comparison of the Silica Monolith Flow-Through Pore-Characterization Data
MICROSCOPIC CHARACTERIZATIONS
Introduction
Preparation of Macroporous Silica Monolith
Laser Scanning Confocal Microscope Observation
Image Processing
Fundamental Parameters
Three-Dimensional Observation of Deformations in Confined Geometry
MODELING CHROMATOGRAPHIC BAND BROADENING IN MONOLITHIC COLUMNS
Introduction
The General Plate-Height Model
User of the General Plate-Height Model to Predict Band Broadening in TSM Structures
Conclusion
COMPARISON OF THE PERFORMANCE OF PARTICLE-PACKED AND MONOLITHIC COLUMNS IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Introduction
Basic Columns Properties
Comparison of the Through-Pore Structures and Related Properties
Thermodynamic Properties
Kinetic Properties and Column Efficiency
Conclusions
PART III: Applications
QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIPS IN STUDIES OF MONOLITHIC MATERIALS
Fundamentals of Quantitative Structure-Retention Relationships (QSSR)
Quantitative Relationships between Analyte Hydrophobicity and Retention on Monolithic Columns
QSSR Based on Structural Descriptors from Calculation Chemistry
LSER on Monolithic Columns
Concluding Remarks
PERFORMANCE OF SILICA MONOLITHS FOR BASIC COMPOUNDS. SILANOL ACTIVITY
Introduction
Reproducibility of Commercial Monoliths for Analysis of Bases
Activity of Monoliths towards Basic Solutes
Contribution of Overload to Peak Shapes of Basic Solutes
Van Deemter Plots for Commercial Monoliths
Performance of Hybrid Capillary Silica Monoliths for Basic Compounds
QUALITY CONTROL OF DRUGS
Introduction
Analysis of Pharmaceutics
Natural Products Analysis
Analysis Speed and Performance
Method Transfer
Separation of Complex Mixtures
Monolithic Derivatives and Versatile Application
Summary and Conclusions
MONOLITHIC STATIONARY PHASES FOR FAST ION CHROMATOGRAPHY
Fast Ion Chromatography
Historical Development of Fast Ion Chromatography
3 Advantages of the Bimodal Porous Structure of the Silica Monolith Matrix
Type and Properties of Silica Monolithic Columns Used in IC
Modification of Silica Monoliths for IC Separations
Operational Parameters
Analytical Applications
Future Work
MONOLITHIC CHIRAL STATIONARY PHASES FOR LIQUID-PHASE ENANTIOSEPARATION TECHNIQUES
Introduction
Organic Monolithic Materials for the Separation of Enantiomers
Silica-Based Monolithic Materials for the Separation of Enantiomers
Summary of the Present State-of-the-Art and Problems to be Solved in the Future
HIGH-SPEED AND HIGH-EFFICIENCY SEPARATIONS BY UTILIZING MONOLITHIC SILICA CAPILLARY COLUMNS
Introduction
Preparation of Monolithic Silica Capillary Columns
Properties of Monolithic Silica Capillary Columns
Monolithic Silica Capillary Columns for High-Efficiency Separations
Monolithic Silica Capillary Columns for High-Speed Separations
Future Considerations
SILICA MONOLITHIC COLUMNS AND MASS SPECTROMETRY
Introduction
Offline Chromatography, LC MALDI MS
Online ESI LC/MS/MS for Proteomics and Selected Reaction Monitoring (SRM)
Online Reactors and Affinity Columns Coupled to Mass Spectrometry
Conclusion
SILICA MONOLITHS FOR SMALL-SCALE PURIFICATION OF DRUG-DISCOVERY COMPOUNDS
Introduction
Instrumental and Operating Considerations
Preparative Separations and Sample Loading
Purification of Drug-Discovery Compounds
Conclusions
MONOLITHIC SILICA COLUMNS IN MULTIDIMENSIONAL LC-MS FOR PROTEOMICS AND PEPTIDOMICS
Introduction
Liquid Chromatography as a Tool Box for Proteomics
Selectivity of Columns for MD-LC
Dimensions of Columns in MD-LC
Monolithic Silica Columns
Applications of Monolithic Silica in Proteomics -
A Brief Survey
Summary and Conclusions
SILICA MONOLITHS IN SOLID-PHASE EXTRACTION AND SOLID-PHASE MICROEXTRACTION
Introduction
Extraction Process
Extraction Platforms
Applications
Conclusion and Outlook
「Nielsen BookData」 より