{"@context":{"owl":"http://www.w3.org/2002/07/owl#","bibo":"http://purl.org/ontology/bibo/","foaf":"http://xmlns.com/foaf/0.1/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/"},"@id":"https://ci.nii.ac.jp/ncid/BB08566447.json","@graph":[{"@id":"https://ci.nii.ac.jp/ncid/BB08566447#entity","@type":"bibo:Book","foaf:isPrimaryTopicOf":{"@id":"https://ci.nii.ac.jp/ncid/BB08566447.json"},"dc:title":[{"@value":"Enzyme inhibition in drug discovery and development : the good and the bad"}],"dc:creator":"edited by Chuang Lu, Albert P. Li","dc:publisher":[{"@value":"Wiley"}],"dcterms:extent":"xiii, 854 p., [8] p. of plates","cinii:size":"25 cm","dc:language":"eng","dc:date":"2010","cinii:ncid":"BB08566447","cinii:ownerCount":"4","foaf:maker":[{"@type":"foaf:Person","foaf:name":[{"@value":"Lu, Chuang"}]},{"@id":"https://ci.nii.ac.jp/author/DA06695619#entity","@type":"foaf:Person","foaf:name":[{"@value":"Li, A. 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Miwa","Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh","Bioanalytical technologies in drug discovery / Jing-Tao Wu","Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk","The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan","Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.]","Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach","Cytochrome P450 induction / Edward L. LeCluyse ... [et al.]","Inhibition of drug-metabolizing enzymes in the gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston","Enzyme inhibition in various in vitro systems / Ping Zhao","Cytochrome P450 Degradation and its clinical relevance / Mingxiang Liao ... [et al.]","Complexities of working with UDP-Giucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher","Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu","Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani","Transporter-Xenobiotic Interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner","Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang","Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt","Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan","NF-KB : mechanism, tumor biology, and inhibitors / Lenny Dang","G-Protein-Coupled receptors as drug targets / Wenyan Miao and Lijun Wu","Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin","Targeting the mTOR pathway for tumor therapeutics / Wei Chen","HIV-1 protease inhibitors as antiretroviral agents / Selgei V. Gulnik, Elena Afonina, and Michael Eissenstat"],"foaf:topic":[{"@id":"https://ci.nii.ac.jp/books/search?q=Enzyme+inhibitors","dc:title":"Enzyme inhibitors"},{"@id":"https://ci.nii.ac.jp/books/search?q=Drug+development","dc:title":"Drug development"},{"@id":"https://ci.nii.ac.jp/books/search?q=Drugs+--+Metabolism","dc:title":"Drugs -- Metabolism"},{"@id":"https://ci.nii.ac.jp/books/search?q=Enzyme+Inhibitors+--+pharmacology","dc:title":"Enzyme Inhibitors -- pharmacology"},{"@id":"https://ci.nii.ac.jp/books/search?q=Drug+Discovery+--+methods","dc:title":"Drug Discovery -- methods"},{"@id":"https://ci.nii.ac.jp/books/search?q=Enzyme+Inhibitors+--+chemical+synthesis","dc:title":"Enzyme Inhibitors -- chemical synthesis"}],"dcterms:hasPart":[{"@id":"urn:isbn:9780470281741","dc:title":": cloth"}]}]}