Antipsychotic trials in schizophrenia : the CATIE project
著者
書誌事項
Antipsychotic trials in schizophrenia : the CATIE project
（Cambridge medicine）
Cambridge University Press, 2010
- : hardback
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注記
Includes bibliographical references and index
収録内容
- Study design and protocol development process / T. Scott Stroup, Joseph P. McEvoy, and Jeffrey A. Lieberman
- Statistical considerations / Sonia M. Davis ... [et al.]
- Effectiveness and efficacy : staying on treatment and symptom reduction / Joseph P. McEvoy, T. Scott Stroup, and Jeffrey A. Lieberman
- Cost-effectiveness and cost-benefit analysis / Robert A. Rosenbeck and Douglas L. Leslie
- Psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study / Marvin S. Swartz
- Neurocognition / Richard S. E. Keefe
- Vocational outcomes / Sandra G. Resnick and Robert A. Rosenbeck
- Family outcomes / Deborah A. Perlick, Richard Kaczynski, and Robert A. Rosenbeck
- Extrapyramidal side effects / Stanley N. Caroff, Del D. Miller, and Robert A. Rosenbeck
- Metabolic side effects and risk of cardiovascular disease / Jonathan M. Meyer, Donald C. Goff, and Joseph P. McEvoy
- Substance use in persons with schizophrenia : incidence, baseline correlates, and effects on outcome / Fred Reimherr, Marvin S. Swartz, and John L. Olsen
- Violence in schizophrenia : prevalence, correlates, and treatment effectiveness / Jeffrey Swanson and Richard VanDorn
- Genetic investigations in the CATIE sample / James J. Crowley and Patrick F. Sullivan
- Human subjects considerations / T. Scott Stroup and Paul Appelbaum
- Population pharmacokinetics of antipsychotics / Kristin L. Bigos ... [et al.]
- Implications for research design and study implementation / T. Scott Stroup and Jeffrey A. Lieberman
- Conclusion and implications for practice and policy / Robert A. Rosenheck, T. Scott Stroup, and Jeffrey A. Lieberman
内容説明・目次
内容説明
Antipsychotic medications are a key treatment for schizophrenia and sales of antipsychotic drugs approach $20 billion per year, with fierce marketing between the makers of the drugs. The U.S. National Institute of Mental Health sponsored the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project to provide independent information about the comparative effectiveness of medications. CATIE was the largest, longest and most comprehensive study of schizophrenia to date. Conducted under rigorous double-blind conditions, Antipsychotic Trials in Schizophrenia presents the definitive archival results of this landmark study. The core of the book consists of chapters focused on specific outcomes that set the CATIE findings in a wider context. Also included are chapters on the design, statistical analyses and implications for researchers, clinicians and policy makers. Psychiatrists, psychiatric researchers, mental health policy makers and those working in pharmaceutical companies will all find this to be essential reading.
目次
- List of contributors
- Acknowledgements
- Introduction
- 1. Study design and protocol development process T. Scott Stroup, Joseph P. McEvoy and Jeffrey A. Lieberman
- 2. Statistical considerations Sonia M. Davis, Gary G. Koch, Robert A. Rosenheck and Vicki G. Davis
- 3. Effectiveness and efficacy: staying on treatment and symptom reduction Joseph P. McEvoy, T. Scott Stroup and Jeffrey A. Lieberman
- 4. Cost-effectiveness and cost-benefit analysis Robert A. Rosenheck and Douglas L. Leslie
- 5. Psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study Marvin S. Swartz
- 6. Neurocognition Richard S. E. Keefe
- 7. Vocational outcomes Sandra G. Resnick and Robert A. Rosenheck
- 8. Family outcomes Deborah A. Perlick, Richard Kaczynski and Robert A. Rosenheck
- 9. Extrapyramidal side effects Stanley N. Caroff, Del D. Miller and Robert A. Rosenheck
- 10. Metabolic side effects and risk of cardiovascular disease Jonathan M. Meyer, Donald C. Goff and Joseph P. McEvoy
- 11. Substance use in persons with schizophrenia: incidence, baseline correlates, and effects on outcome Fred Reimherr, Marvin S. Swartz and John L. Olsen
- 12. Violence in schizophrenia: prevalence, correlates, and treatment effectiveness Jeffrey Swanson and Richard Van Dorn
- 13. Genetic investigations in the CATIE sample James J. Crowley and Patrick F. Sullivan
- 14. Human subjects considerations T. Scott Stroup and Paul Appelbaum
- 15. Population pharmacokinetics of antipsychotics Kristin L. Bigos, Robert R. Bies, Stephen R. Marder and Bruce G. Pollock
- 16. Implications for research design and study implementation T. Scott Stroup and Jeffrey A. Lieberman
- 17. Conclusion and implications for practice and policy Robert A. Rosenheck, T. Scott Stroup and Jeffrey A. Lieberman.
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