Antibody expression and production
Author(s)
Bibliographic Information
Antibody expression and production
(Cell engineering, v. 7)
Springer, c2011
Available at 2 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes bibliographical references and index
Description and Table of Contents
Description
Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.
Table of Contents
1 Expression of antibody in mammalian cells, Thomas Jostock.- 2 Bioreactor systems for producing antibody from mammalian cells, Darrin Kuystermans and Mohamed Al-Rubeai.- 3 Production of antibody in insect cells, Hideki Yamaji.- 4 Production of monoclonal antibodies in glycoengineered Pichia pastoris, Dongxing Zhu, Thomas Linden and Thomas Potgieter.- 5 Production of antibodies in Hansenula polymorpha, Georg Melmer, Stephan Hellwig, Grit Hehmann and Ulrike Dahlems.- 6 Expression of antibody in transgenic avians, Yoshinori Kawabe and Masamichi Kamihira.- 7 Production of antibodies in plants, Alejandro Sarrion-Perdigones, Paloma Juarez, Antonio Granell and Diego Orzaez.- 8 Production of antibody fab fragments in Escherichia coli, Hiroshi Tachibana and Masataka Takekoshi.- 9 Intrabody expression in mammalian cells, Silvia Biocca.- 10 Engineering of antibodies for cancer therapy, Lisa E. Goldsmith and Matthew K. Robinson.- 11 Recombinant bispecific antibodies for cancer therapy, Dafne Muller and Roland Kontermann.- 12 The role of glycosylation in therapeutic antibodies, Maureen Spearman, Ben Dionne and Mike Butler.- 13 Quality issues arising from post-translational modification of recombinant antibodies, Raymond Tyther and Nigel Jenkins.- 14 Purification of antibody, XueJun Han, Arther Hewig and Ganesh Vedantham.- Index
by "Nielsen BookData"