Fuzziness : structural disorder in protein complexes
著者
書誌事項
Fuzziness : structural disorder in protein complexes
（Advances in experimental medicine and biology, v. 725）
Springer Science+Business Media , Landes Bioscience, c2012
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注記
Includes bibliographical references and index
収録内容
- Fuzzy complexes : a more stochastic view of protein function / Monika Fuxreiter and Peter Tompa
- Dynamic fuzziness during linker histone action / Steven J. McBryant and Jeffrey C. Hansen
- Intrinsic protein flexibility in regulation of cell proliferation : advantages for signaling and opportunities for novel therapeutics / Ariele Viacava Follis, Charles A. Galea, and Richard W. Kriwacki
- Interplay between protein order, disorder and oligomericity in receptor signaling / Alexander B. Sigalov
- Consequences of fuzziness in the NFB/IB interaction / Elizabeth A. Komives
- Roles for intrinsic disorder and fuzziness in generating context specific function in ultrabithorax : a hox transcription factor / Sarah E. Bondos and Hao Ching Hsiao
- Molecular recognition by the EWS transcriptional activation domain / Kevin A.W. Lee
- The measles virus NTAILXD complex : an illustrative example of fuzziness / Sonia Longhi
- Fuzziness in the core of the human pathogenic viruses HCV and HIV / Roland Ivanyi-Nagy and Jean-Luc Darlix
- Structural disorder and protein elasticity / Sarah Rauscher and Røgis Pomès
- "Fuzziness" in the cellular interactome : a historical perspective / G. Rickey Welch
内容説明・目次
内容説明
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
目次
Fuzzy Complexes: A More Stochastic View of Protein Function.- Dynamic Fuzziness During Linker Histone Action.- Protein Flexibility in Regulation of Cell Proliferation: Advantages for Signaling and Opportunities for Novel Therapeutics.- Interplay Between Protein Order, Disorder and Oligomericity in Receptor Signaling.- Consequences of Fuzziness in the NFkB/IkBa Interaction.- Roles for Intrinsic Disorder and Fuzziness in Generating Context- Specific Function in Ultrabithorax, a Hox Transcription Factor.- Molecular Recognition by the EWS Transcriptional Activation Domain.- The Measles Virus Ntail-Xd Complex: An Illustrative Example of Fuzziness.- Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV.- Structural Disorder and Protein Elasticity.- "Fuzziness" in the Cellular Interactome: A Historical Perspective.
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