Gerontological aspects of genome peptide regulation
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Bibliographic Information
Gerontological aspects of genome peptide regulation
Karger, c2005
- : hard cover
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Note
Includes bibliographical references and index
Contents of Works
- Anti-aging mechanisms of peptides
- Estimation of peptides effect on gene expression in mouse heart using DNA-microarray technology
- Effect of peptides on IL-2 gene expression
- Effect of peptides on c-fos gene expression in stress
- Effect of peptides on carcinogenesis in transgenic mice
- Effect of peptides on chromosomes
- Effect of epitalon on telomerase activity, telomere elongation and proliferative potential in human somatic cells
- Effect of peptides on DNA synthesis
- Interaction between small peptides and DNA double helix
- From anti-aging peptide regulation to pharmacogenomics
Description and Table of Contents
Description
This monograph highlights the gerontological aspects of the peptide regulation of gene expression. It focuses on the mechanisms of the geroprotective action of peptides related to chromatin activation, increase in telomerase enzyme activity, and elongation of telomeres in different cells. A key role in the initiation of the biological activity of peptide is its interaction with DNA which provides genetic stability and a normalization of the age-related metabolic shifts. Study of the genetic mechanisms of peptide action suggests a new concept which most comprehensively reflects on the evolutionary biological role peptide plays in the organism. The impact of peptides on the expression and structure of genes opens a new gate for the prevention of premature aging and age-related pathology which appears to be most promising in pharmacogenomics. This monograph narrates not only the theoretical aspects and experimental data, but also outlines new approaches to the prevention of aging and age-related pathology, thus addressing a wide readership of gerontologists, geneticists, molecular biologists, biochemists, and pharmacologists alike.
Table of Contents
- Preface
- Acknowledgements
- Anti-Aging Mechanisms of Peptides
- Estimation of Peptides Effect on Gene Expression in Mouse Heart Using DNA-Microarray Technology
- Effect of Peptides on IL-2 Gene Expression
- Effect of Vilon and Epitalon on IL-2 Gene Expression in Mouse Spleen Lymphocytes
- Effect of Vilon and Epitalon on IL-2 Gene Expression in Rat Hypothalamus Structures
- Effect of Peptides on c-fos Gene Expression in Stress
- Effect of Vilon on c-fos Gene Expression in Neurons of Rat Hypothalamic Paraventricular Nucleus under Emotional Stress
- Effect of Vilon and Epitalon on c-fos Gene Expression in Cells of Different Hypothalamic Structures in Rats under 'Handling' Stress
- Effect of Epitalon on c-fos Protein Content in the Pineal Gland of Rats Exposed to Osmotic Stress
- Effect of Peptides on Carcinogenesis in Transgenic Mice
- Effect of Peptides on Chromosomes
- Effect of Vilon and Epitalon on Number of Chromosome Aberrations in Corneal Epithelium and Bone Marrow Cells of Hypokinesic Rats
- Effect of Epitalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice
- Effect of Vilon and Epitalon on Nucleolus Organizers in Human Thymic Cells
- Effects of Small Peptides on Blood Lymphocyte Chromatin in Senile Humans
- Effect of Epitalon on Telomerase Activity, Telomere Elongation and Proliferative Potential in Human Somatic Cells
- Effect of Peptides on DNA Synthesis
- Effect of Vilon on DNA Synthesis in Rat Thymus Cells under the Influence of Nitrites
- Effect of Vilon on DNA Synthesis in Blood Leukocytes of Old Rats Exposed to Small-Dose Radiochemical Impact
- Effect of Vilon on Mitotic Activity of Hepatocytes in Rats after Partial Hepatectomy
- Interaction between Small Peptides and DNA Double Helix
- Peculiarities of Complementary Interaction in the 'Peptide - DNA' System
- Model of Complementary Interaction between Small Peptides and DNA
- Informational Interaction in the 'Peptide - DNA' System
- From Anti-Aging Peptide Regulation to Pharmacogenomics
- Conclusion
- References
- Subject Index.
by "Nielsen BookData"
