Endothelin in renal physiology and disease
Author(s)
Bibliographic Information
Endothelin in renal physiology and disease
(Contributions to nephrology, v. 172)
Karger, c2011
Available at 3 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
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  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
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  United Kingdom
  Germany
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine. The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development.
Table of Contents
- Preface
- Molecular Biology and Physiology of Endothelin in the Kidney
- Pharmacology of Renal Endothelin Receptors: Davenport, A.P.
- Maguire, J.J.
- Renal Function and Blood Pressure: Molecular Insights into the Biology of Endothelin-1: Vignon-Zellweger, N.
- Heiden, S.
- Emoto, N.
- Endothelin and the Renal Vasculature: Guan, Z.
- Inscho, E.W.
- Endothelin Signaling and Actions in the Renal Mesangium: Sorokin, A.
- Regulation of Sodium Transport in the Proximal Tubule by Endothelin: Zhang, Y.
- Jose, P.A.
- Zeng, C.
- Role of Endothelin in Thick Ascending Limb Sodium Chloride Transport: Ramseyer, V.D.
- Cabral, P.D.
- Garvin, J.L.
- Endothelins and Kidney Acidification: Wesson, D.E.
- Endothelin and Collecting Duct Sodium and Water Transport: Kohan, D.E.
- Endothelin Control of Renal Sympathetic Nerve Activity: Kopp, U.C.
- Pathophysiology: Endothelin and Renal Disease Mechanisms
- Endothelin and Podocyte Injury in Chronic Kidney Disease: Fligny, C.
- Barton, M.
- Tharaux, P.-L.
- Endothelin in Diabetic Renal Disease: Benz, K.
- Amann, K.
- Endothelin, Nitric Oxide, and Reactive Oxygen Species in Diabetic Kidney Disease: Pollock, J.S.
- Pollock, D.M.
- Endothelin in Renal Inflammation and Hypertension: Saleh, M.A.
- Pollock, D.M.
- Endothelin in Chronic Proteinuric Kidney Disease: Gagliardini, E.
- Buelli, S.
- Benigni, A.
- Endothelin in Renal Injury due to Sickle Cell Disease: Tharaux, P.-L.
- Endothelin in Polycystic Kidney Disease: Chang, M.-Y.
- Ong, A.C.M
- Clinical Studies of Endothelin Antagonism in Renal Disease Patients
- Endothelin Antagonism and Reversal of Proteinuric Renal Disease in Humans: Barton, M.
- Endothelin Antagonism in Patients with Resistant Hypertension and Hypertension Nephropathy: Lazich, I.
- Bakris, G.L.
- Endothelin Receptor Blockade in Diabetic Nephropathy: Rabelink, T.J.
- Kohan, D.E.
- Endothelin Antagonism in Patients with Nondiabetic Chronic Kidney Disease: Dhaun, N.
- Goddard, J.
- Webb, D.J.
- Endothelin Antagonists in Clinical Trials: Lessons Learned: Barton, M.
- Kohan, D.E.
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