Oxidative stress : diagnostics, prevention, and therapy
著者
書誌事項
Oxidative stress : diagnostics, prevention, and therapy
（ACS symposium series, 1083,
American Chemical Society , Distributed in print by Oxford University Press, 2011-2015
- [v. 1]
- v. 2
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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[v. 1] ISBN 9780841226838
内容説明
Oxidative stress is the state of a diminished capacity of a biological system to counteract an overproduction or invasion of reactive oxygen species and other radicals. This book presents recent advancements in the understanding of oxidative stress, the mechanisms of damage to cells and biomolecules, and pathological implications in disorders including Alzheimer's disease, Parkinson's Disease, cardiovascular disease, cell damage in HIV-AIDS, stroke, autism and
premature aging. The book is a comprehensive source of information describing new directions in diagnostics of oxidative stress, including novel detection methods of oxidative-stress biomarkers, prevention by antioxidants, and therapy using novel free radical scavenging agents and natural defense
systems.
目次
- Preface
- 1. The Role of Antioxidants in Human Health
- Saikat Sen and Raja Chakraborty
- 2. Pathophysiological Implications of Altered Redox Balance in HIV/AIDS Infection: Diagnosis and Counteract Interventions
- L. Gil del Valle, Ph.D.
- 3. Thermodynamics of Free Radical Reactions and the Redox Environment of a Cell
- Klaudia Jomova and Marian Valko
- 4. Oxidative Stress in the Metabolism of Estrogens Leading to Cancer Initiation: Prevention by Specific Antioxidants
- Eleanor G. Rogan and Ercole L. Cavalieri
- 5. Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. coli and Human Cells
- Hsiao C. Wang and Julia L. Brumaghim
- 6. DNA-Protective Mechanisms of Glutathione Intervention in Catechol-Mediated Oxidative DNA Damage in the Presence of Copper(II) Ions
- Maria Hepel, Magdalena Stobiecka, Janet Peachey, and Jeremiah Miller
- 7. Antioxidant Effectiveness in Preventing Paraquat-Mediated Oxidative Dna Damage in the Presence of H2O2
- Magdalena Stobiecka, Amanda Prance, Kaitlin Coopersmith, and Maria Hepel
- 8. Artificial Nanoparticle Antioxidants
- Erica Sharpe, Daniel Andreescu, and Silvana Andreescu
- 9. Cerium Oxide Nanoparticles for the Treatment of Neurological Oxidative Stress Diseases
- A. Y. Estevez and J. S. Erlichman
- 10. Detection of Superoxide and Hydrogen Peroxide from Living Cells Using Electrochemical Sensors
- Szilveszter Gaspar
- 11. Peroxynitrite and Nitroxidative Stress: Detection Probes and Micro-Sensors. A Case of a Nanostructured Catalytic Film
- Serban F. Peteu, Saleem Banihani, Mutha M. Gunesekera, Pubudu Peiris, Oana A. Sicuia, and Mekki Bayachou
- 12. Blue Native PAGE and Mass Spectrometry as an Approach for the Investigation of Stable and Transient Protein-Protein Interactions
- Alisa G. Woods, Izabela Sokolowska, Rama Yakubu, Melissa Butkiewicz, Martin LaFleur, Christopher Talbot, and Costel C. Darie
- 13. Mass Spectrometry for Proteomics-Based Investigation of Oxidative Stress and Heat Shock Proteins
- Izabela Sokolowska, Alisa G. Woods, Jessica Wagner, Jeannette Dorler, Kelly Wormwood, Johannes Thome, and Costel C. Darie
- Editors' Biographies
- Author Index
- Subject Index
- 巻冊次
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v. 2 ISBN 9780841231009
内容説明
This book provides a comprehensive overview of the oxidative stress related mechanisms in biological systems and the involvement of reactive oxygen and nitrogen species (ROS and RNS), the damage of DNA, proteins, and lipids caused by oxidative stress, the protection of cells and tissues against free radicals, the relation of the oxidative stress to aging and human diseases including cancer and neurological disorders, and the development of new therapeutic approaches
to modulate oxidative stress. The current state-of-the-art methodologies including the development of sensors and biosensors for the detection of ROS/RNS and of biomarkers of oxidative stress are also discussed.
The book is organized in three overlapping parts, starting with general considerations of the oxidative stress, homeostasis pathways, and ROS mechanisms, followed by chapters discussing the involvement of ROS in particular diseases and concluding with analytical aspects of oxidative stress monitoring. The book provides a solid background on oxidative stress and ROS/RNS generation for novice learners while also offering scientists and practitioners already involved in this field a wealth of
information covering the most recent developments in the study of oxidative stress, the role of radical species, novel antioxidant therapies, and methods for assessing free radicals and oxidative stress.
目次
1. Oxidative Stress and Human Health
2. Oxidative Metabolism of Estrogens in Cancer Initiation and Prevention
3. Oxidative Stress, Redox Homeostasis and NF-kB Signaling in Neurodegeneration
4. Oxidative Inactivation of Nitric Oxide and Peroxynitrite Formation in the Vasculature
5. Oxidative Stress in Parkinson's Disease: Role in Neurodegeneration and Targets for Therapeutics
6. Oxidative Stress in the Aging Process: Fundamental Aspects and New Insights
7. Unifying Mechanism of Antiviral Drug Action Based on Electron Transfer and Reactive Oxygen Species
8. Triclosan (Mechanism of Bactericidal Action and Toxicity): Metabolism, Electron Transfer and Reactive Oxygen Species
9. MTIP and Flavins: Alcoholism Drugs, Electron Transfer, and Reactive Oxygen Species
10. How Does Acetaminophen Function? Metabolite, Electron Transfer, Reactive Oxygen Species, Oxidative Stress and COX
11. Aspirin (Analgesic) and Dicamba (Herbicide): Electron Transfer, Reactive Oxygen Species, Oxidative Stress, and Antioxidant
12. DNA Damage by Highly Oxidizing Environmental Pollutants
13. Electrochemical Biosensors for Real-Time Monitoring of Reactive Oxygen and Nitrogen Species
14. Redox Activity of Oxidative Stress-Damping Endogenous Thiol Biomolecules
15. Oxidative Stress Biomarkers and ROS Molecular Probes
16. Impact of Artifactual Ex Vivo Oxidation on Biochemical Research
17. Scanning Electrochemical and Fluorescence Microscopy for Detection of Reactive Oxygen Species in Living Cells
18. Toward a Synthetic View of the Therapeutic Use of Cerium Oxide Nanoparticles for the Treatment of Neurodegenerative Diseases
19. Nanomaterials Induced Cell Damage
20. Free Radicals in Mycobacterial Disease
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