Radiation damage in biomolecular systems
著者
書誌事項
Radiation damage in biomolecular systems
(Biological and medical physics, biomedical engineering)
Springer, c2012
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection.
Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada, the USA and Australia.
This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems.
An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments.
目次
Preface.- Acronyms.
Part I Radiation Induced Damage at the Molecular Level
1: Nanoscale Dynamics of Radiosensitivity: Role of Low Energy Electrons.- 2: The Role of Secondary Electrons in Radiation Damage.- 3: Electron Transfer-Induced Fragmentation in (Bio)Molecules by Atom-Molecule.- 4: Following Resonant Compound States after Electron Attachment.- 5: Electron-Biomolecule Collision Studies Using the Schwinger Multichannel Method.- 6: Resonances in Electron Collisions with Small Biomolecules Using the R-Matrix Method.- 7: A Multiple-Scattering Approach to Electron Collisions with Small Molecular Clusters.- 8: Positronium Formation and Scattering from Biologically Relevant Molecules.- 9: Total Cross Sections for Positron Scattering from Bio-Molecules.- 10: Soft X-ray Interaction with Organic Molecules of Biological Interest.- 11: Ion-Induced Radiation Damage in Biomolecular Systems.- 12: Theory and Calculation of Stopping Cross Sections of Nucleobases for Swift Ions.
Part II Modelling Radiation Damage
13: Monte Carlo Methods to Model Radiation Interactions and Induced Damage.- 14: Positron and Electron Interactions and Transport in Biological Media.- 15: Energy Loss of Swift Protons in LiquidWater: Role of Optical Data Input and Extension Algorithms.- 16: Quantum-Mechanical Contributions to Numerical Simulations of Charged Particle Transport at the DNA Scale.- 17: Multiscale Approach to Radiation Damage Induced by Ions.- 18: Track-Structure Monte Carlo Modelling in X-ray and Megavoltage Photon Radiotherapy.- 19: Simulation of Medical Linear Accelerators with PENELOPE.
Part III Biomedical Aspects of Radiation Effects
20: Repair of DNA Double-Strand Breaks.- 21: Differentially Expressed Genes Associated with Low-Dose Gamma Radiation.- 22: Chromosome Aberrations by Heavy Ions.- 23: Spatial and Temporal Aspects of Radiation Response in Cell and Tissue Models.- 24: Therapeutic Applications of Ionizing Radiations.- 25: Optimized Molecular Imaging through Magnetic Resonance for Improved Target Definition in Radiation Oncology.
Part IV Future Trends in Radiation Research and its Applications
26: Medical Applications of Synchrotron Radiation.- 27: Photodynamic Therapy.- 28: Auger Emitting Radiopharmaceuticals for Cancer Therapy.- 29: Using a matrix approach in nonlinear beam dynamics for optimizing beam spot size.- 30 Future Particle Accelerator Developments for Radiation Therapy.Part III Biomedical Aspects of Radiation Effects
20: Repair of DNA Double-Strand Breaks.- 21: Differentially Expressed Genes Associated with Low-Dose Gamma Radiation.- 22: Chromosome Aberrations by Heavy Ions.- 23: Spatial and Temporal Aspects of Radiation Response in Cell and Tissue Models.- 24: Therapeutic Applications of Ionizing Radiations.- 25: Optimized Molecular Imaging through Magnetic Resonance for Improved Target Definition in Radiation Oncology.
Part IV Future Trends in Radiation Research and its Applications
26: Medical Applications of Synchrotron Radiation.- 27: Photodynamic Therapy.- 28: Auger Emitting Radiopharmaceuticals for Cancer Therapy.- 29: Using a matrix approach in nonlinear beam dynamics for optimizing beam spot size.- 30 Future Particle Accelerator Developments for Radiation Therapy.Part IV Future Trends in Radiation Research and its Applications
26: Medical Applications of Synchrotron Radiation.- 27: Photodynamic Therapy.- 28: Auger Emitting Radiopharmaceuticals for Cancer Therapy.- 29: Using a matrix approach in nonlinear beam dynamics for optimizing beam spot size.- 30: Future Particle Accelerator Developments for Radiation Therapy.
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