Progress in the chemistry of organic natural products
著者
書誌事項
Progress in the chemistry of organic natural products
Springer, 2011-
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大学図書館所蔵 件 / 全14件
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注記
94: Authors, S.S. Ebada ...[et al.]
99: Authors, Feng Qiu ...[et al.]
100: Authors, U. Wagner ...[et al.]
102,104-106: Editors, A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi
107-110: Editors, A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, Yoshinori Asakawa, Ji-Kai Liu
内容説明・目次
- 巻冊次
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108 ISBN 9783030010980
内容説明
The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.
目次
Chemistry and biology of selected Mexican medicinal plants.- Biomolecular targets of oxyprenylated phenylpropanoids and polyketides.- Secondary metabolites of endophytic actinomycetes: isolation, synthesis, biosynthesis, and biological activities.
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109 ISBN 9783030128579
内容説明
This volume comprises three reviews. The first describes isolation, structure determination, syntheses, and biochemistry of the low molecular weight compounds of the secretion of exocrine glands of termies with emphasis to pheromones and defensive compounds. The second review describes recent studies on isolation and structure elucidation of bioactive compounds involved in the life cycle and determination of the molecular mechanisms of the developmental events observed in higher plants. The third contribution reports on the current body of knowledge of African propolis, with a particular emphasis on its chemistry and biological activity.
目次
Chemistry of the Secondary Metabolites of Termites.- Bioactive Compounds in the Life Cycle of Higher Plants.- Chemical Diversity and Biological Activity of African Propolis.
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110 ISBN 9783030146313
内容説明
The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
目次
Resources for chemical, biological, and structural data on natural product.- The pharmacophore concept and its applications in computer-aided drug design.- Chemical space of natural products.- Cheminformatics analysis for natural product fragments.- A toolbox for the identification of modes of action of natural products.- A SWOT analysis of Cheminformatics in natural product research.- Open access prediction tools for natural products. Case study: hERG blockers.
- 巻冊次
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111 ISBN 9783030378646
内容説明
The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature.
The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.
目次
Sesterterpenoids.- Secondary Metabolites from Marine-Derived Fungi from China.
- 巻冊次
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99 ISBN 9783319048994
内容説明
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin.
The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
目次
Pharmacognosy of Black Cohosh: the phytochemical and biological profile of a major botanical dietary supplement. - The evolution of Indigoids: a colorful history. - Bioactive heterocyclic natural products from actinomycetes having effects on cancer-related signaling pathways. - Genome mining: concept and strategies for natural product discovery.
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100 ISBN 9783319052748
内容説明
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board.
The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
目次
H. Budzikiewicz: Mass spectrometry in natural product structure elucidation.- C. Kratky, U. Wagner: Structure elucidation of natural compounds by X-ray crystallography.- P. Joseph-Nathan, B. Gordillo-Roman: VCD absolute configuration determination of natural products.- R. W. Soukup: Progress in the Chemistry of Organic Natural Products: 75 years at the service of the development of natural product chemistry.- E. P. Mazzola, W. F. Reynolds: Nuclear magnetic resonance in the structural elucidation of natural products.
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101 ISBN 9783319226910
内容説明
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, and H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
目次
Dimeric Sesquiterpenoids.- Acetogenins from Annonaceae.
- 巻冊次
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102 ISBN 9783319331706
内容説明
The first contribution reviews the phytochemical, chemical,
and biological literature on members of the ingenane class of diterpenoids from
their first isolation in 1968 through 2015, highlighting unresolved issues both
common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the
light of the Jakupovic proposal of a dissection between the formation of the macrocyclic
Euphorbia diterpenoids and the phorboids,
and the clinical development of ingenol mebutate is chronicled in the light of
its "reverse-pharmacology" focus.
The second contribution
offers a comprehensive view of the chemical wealth and the taxonomic problems
currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and
population dynamics of the genus, as well as its chemical diversity and ecological
relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
目次
The Laurencia paradox:an endless source of chemodiversity. - Ingenane Dipernoids.
- 巻冊次
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104 ISBN 9783319456164
内容説明
The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis.
The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.
目次
Natural product molecular fossils.- Phthalides: distribution in nature, chemical reactivity, synthesis, and biological activity.
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105 ISBN 9783319497112
内容説明
The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.
目次
Xanthine Alkaloids: occurrence, biosynthesis, and function in plants.- The Iboga Alkaloids.- A critical evaluation of the quality of published 13C-NMR-Data in natural product chemistry.
- 巻冊次
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106 ISBN 9783319595412
内容説明
The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms.
目次
Naturally occurring Coumarins.- Human deiminases: isoforms, substrate specificities, kinetics, and detection.- Secondary metabolites from higher fungi.
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107 ISBN 9783319935058
内容説明
The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types.
The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/anti tumor/anti cancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.
目次
The search for anticancer agents from tropical plants.- Chemistry and biology of Mexican medicinal plants.
- 巻冊次
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94 ISBN 9783709107478
内容説明
The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
目次
S. S. Ebada, N. Lajkiewicz, J. A. Porco Jr., M. Lin-Weber, and P. Proksch: Chemistry and biology of Rocaglamides (=Flavaglines) and related derivatives from Aglaia species (Meliacease). - M. A. R. C. Bulusu, K. Baumann, and A. Stuetz: Chemistry of the immunomodulatory macrolides ascomycin and related analogues. - R. I. Misico, V. Nicotra, J. C. Oberti, G. Barboza, R. R. Gil, and G. Burton: Withanolides and related steroids.
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