Animal models of movement disorders

著者

書誌事項

Animal models of movement disorders

edited by Emma L. Lane, Stephen B. Dunnett

（Springer protocols）（Neuromethods, 61, 62）

Humana Press, c2011

  • v. 1
  • v. 2

大学図書館所蔵 件 / 全3件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

巻冊次

v. 1 ISBN 9781617792977

内容説明

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume I contains general methods of movement disorder assessment as well as an extensive section on dopamine systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

目次

Part I: Generic Methods of Assessment 1. Why Can't a Rodent Be More like a Man?: A Clinical Perspective Anne E. Rosser 2. Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders Maria Sundvik and Pertti Panula 3. Methodological Strategies to Evaluate Functional Effectors Related to Parkinson's Disease through Application of C. elegans Models Kim A. Caldwell and Guy A. Caldwell 4. Effects of Alpha-Synuclein Expression on Behavioral Activity in Drosophila, a Simple Model of Parkinson's Disease Robert G. Pendleton, Xiaoyun C. Yang, Natalie Jerome, Ornela Dervisha, and Ralph Hillman 5. Neurological Evaluation of Movement Disorders in Mice Simon Brooks 6. Rodent Skilled Reaching for Modeling Pathological Conditions of the Human Motor System Jenni M. Karl and Ian Q. Whishaw 7. High Throughput Mouse Phenotyping Sabine M. Hoelter and Lisa Glasl 8. MRI of Neurological Damage in Rats and Mice Mathias Hoehn 9. Quantification of Brain Function and Neurotransmission System In Vivo by Positron Emission Tomography: A Review of Technical Aspects and Practical Considerations in Preclinical Research Nadja Van Camp, Yann Bramoulle, and Philippe Hantraye 10. Optical Approaches to Studying the Basal Ganglia Joshua L. Plotkin, Jaime N. Guzman, Nicholas Schwarz, Geraldine Kress, David L. Wokosin, and D. James Surmeier 11. Electrophysiological Analysis of Movement Disorders in Mice Shilpa P. Rao, Veronique M. Andre, Carlos Cepeda, and Michael S. Levine Part II: Dopamine Systems 12. Genetic Models of Parkinson`s Disease Ralf Kuhn, Daniela Vogt-Weisenhorn, and Wolfgang Wurst 13. 6-OHDA Lesion Models of Parkinson's Disease in the Rat Eduardo M. Torres and Stephen B. Dunnett 14. 6-OHDA Toxin Model in Mouse Gaynor A. Smith and Andreas Heuer 15. Rotation in the 6-OHDA Lesioned Rat Stephen B. Dunnett and Eduardo M. Torres 16. Of Rats and Patients: Some Thoughts about Why Rats Turn in Circles and Parkinson's Disease Patients Cannot Move Normally Gordon W. Arbuthnott 17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson's Disease and Stroke Sheila M. Fleming and Timothy Schallert 18. Rodent Models of L-DOPA-Induced Dyskinesia Hanna S. Lindgren and Emma L. Lane 19. Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson's Disease? Giselle M. Petzinger, Beth E. Fisher, Garnik Akopian, Ruth Wood, John P. Walsh, and Michael W. Jakowec 20. The MPTP Treated Primate, with Specific Reference to the Use of the Common Marmoset (C. jacchus) Michael J. Jackson and Peter Jenner 21. Behavioral Assessment in the African Green Monkey after MPTP Administration D. Eugene Redmond, Jr.
巻冊次

v. 2 ISBN 9781617793004

内容説明

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord. Multiple central nervous systems, including cortex, basal ganglia, cerebellum, and brainstem, interact to provide precise motor control and integration. Damage or disease within these systems cause profound motor disturbances in man, which can be effectively modeled in animals to develop a better understanding and treatment of the human condition. Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders, such as drosophila and c. elegans, through vertebrate species including fish, to mammals, such as rodents and non-human primates. The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behavior. Volume II of this detailed collection contains sections on the basal ganglia, neo- and allo-cortical systems, cerebellar and brain stem systems, as well as spinal cord systems. Comprehensive and meticulous, Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering methodologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field.

目次

Part I: Basal Ganglia 1. Behavioral Assessment of Genetic Mouse Models of Huntington's Disease Miriam A. Hickey and Marie-Francoise Chesselet 2. Excitotoxic Lesions of the Rodent Striatum Mate D Doebroessy, Fabian Buchele, and Guido Nikkhah 3. Combination Lesion Models of MSA Daniela Kuzdas and Gregor K. Wenning 4. The Role of the Dorsal Striatum in Instrumental Conditioning Mark Rossi and Henry H. Yin 5. 3-Nitropropionic Acid and Other Metabolic Toxin Lesions of the Striatum Cesar V. Borlongan and Paul R. Sanberg 6. Functional Assessment of Subcortical Ischemia Tracy D. Farr and Rebecca C. Trueman Part II: Neo- and Allo-Cortical Systems 7. Functional Organization of Rat and Mouse Motor Cortex G. Campbell Teskey and Bryan Kolb 8. Forebrain Circuits Controlling Whisker Movements Kevin D. Alloway and Jared B. Smith 9. An Approach to Understanding the Neural Circuitry of Saccade Control in the Cerebral Cortex Using Antidromic Identification in the Awake Behaving Macaque Monkey Model Kevin Johnston and Stefan Everling 10. Photothrombotic Infarction of Caudate Nucleus and Parietal Cortex Toshihiko Kuroiwa and Richard F. Keep 11. Models of Rodent Cortical Traumatic Brain Injury Frances Corrigan, Jenna M. Ziebell and Robert Vink 12. The Use of Commissurotomy in Studies of Interhemispheric Communication Ian Steele-Russell Part III: Cerebellar and Brain Stem Systems 13. Genetic Models of Cerebellar Dysfunction Robert Lalonde and Catherine Strazielle 14. Cerebellar Control of Fine Motor Function Rachel M. Sherrard 15. Cerebellum and Classical Conditioning Richard F. Thompson 16. Assessments of Visual Function Ma'ayan Semo, Carlos Gias, Anthony Vugler and Peter John Coffey 17. The Role of the Pedunculopontine Tegmental Nucleus in Motor Disorders Nadine K. Gut and Philip Winn Part IV: Spinal Cord Systems 18. Contusion Models of Spinal Cord Injury in Rats Kelly A. Dunham and Candace L. Floyd 19. Demyelination Models in the Spinal Cord Paul A. Felts, Damineh Morsali, Mona Sadeghian, Marija Sajic, and Kenneth J. Smith 20. Preparation of Spinal Cord Injured Tissue for Light and Electron Microscopy Including Preparation for Immunostaining Margaret L. Bates, Raisa Puzis, and Mary Bartlett Bunge 21. Assessing Spinal Cord Injury Gillian D. Muir and Erin J. Prosser-Loose 22. Precise Finger Movements in Monkeys Roger Lemon

「Nielsen BookData」 より

関連文献： 2件中  1-2を表示

詳細情報

ページトップへ