Systems biology : advances in molecular biology and medicine

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Systems biology : advances in molecular biology and medicine

edited by Robert A. Meyers

Wiley-Blackwell, c2012

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Includes bibliographical references and index

Description and Table of Contents

Description

Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.

Table of Contents

Preface and Commentary vii List of Contributors ix Part I Biological Basis of Systems Biology 1 1 Systems Biology 3 Melanie Boerries, Roland Eils, and Hauke Busch 2 Developmental Cell Biology 33 Frank John Dye 3 Principles and Applications of Embryogenomics 51 Vincent VanBuren 4 Interactome 85 Teresa M. Przytycka and Dong-Yeon Cho 5 Protein Abundance Variation 117 Greco Hernandez and Gritta Tettweiler Part II Systems Biology of Evolution 143 6 Genetic Variation and Molecular Darwinism 145 Werner Arber 7 Systematics and Evolution 169 Jeffrey H. Schwartz 8 Evolution of the Protein Repertoire 207 Aaron David Goldman, Jeremy A. Horst, Ling-Hong Hung, and Ram Samudrala Part III Modeling of Biological Systems 237 9 Chaos in Biochemistry and Physiology 239 Miguel Antonio Aon, Sonia Cortassa, and David Lloyd 10 Computational Biology 277 Thomas Lengauer, Mario Albrecht, and Francisco S. Domingues 11 Dynamics of Biomolecular Networks 349 Emanuele Cozzo, Joaquin Sanz, and Yamir Moreno 12 E-Cell: Computer Simulation of the Cell 379 Pawan K. Dhar, Kouichi Takahashi, Yoichi Nakayama, and Masaru Tomita 13 Fractals in Biology and Medicine 397 Gabriele Angelo Losa 14 Models of Cell Migration 423 Michael Meyer-Hermann and Tilo Beyer 15 Protein Modeling 469 Marian R. Zlomislic, Valentina Corradi, and D. Peter Tieleman 16 System Models for Inference on Mechanisms of Neuronal Dynamics 505 Klaas E. Stephan and Karl J. Friston 17 Systems Biology of the Liver 539 Ian David Lockhart Bogle, Rajiv Jalan, Elizabeth Shephard, Robert Seymour, Antony Finkelstein, Thomas Sumner, and Anne Warner Part IV Systems Biology in Medicine and Disease 563 18 Inferring Networks for Diseases 565 Mikael Benson and Michael A. Langston 19 Personalized Medicine (Predictive and Preventive) 593 Alette M. Wessels, Robert R. Bies, and John Urquhart Part V Systems Biology of Organisms 625 20 Microbiomes 627 Ramana Madupu, Yu-Hui Rogers, Doug Rusch, Jason Miller, Konstantinos Krampis, and Karen E. Nelson 21 Synthetic Biology: Implications and Uses 653 Sanjay Vashee, Mikkel A. Algire, Michael G. Montague, and Michele S. Garfinkel 22 Plant Systems Biology 685 Sonia Osorio and Alisdair R. Fernie Index 699

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