Chirality in biological nanospaces : reactions in active sites
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Bibliographic Information
Chirality in biological nanospaces : reactions in active sites
CRC Press, c2012
- : hardback
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Includes bibliographical references and index
Description and Table of Contents
Description
Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers:
Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency
The conserved features of the organization of the active site structures of enzymes
The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions
Interactions between the active site residues and the substrate molecules
Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.
Table of Contents
Introduction. Chiral discrimination in the active site of oxidoreductase. Transferases and chiral discrimination. Influence of chirality on the hydrolysis reactions within the active site of hydrolases. Influence of chirality on the reactions in the active site of lyases. Chiral discrimination in the active site of ligases. Summary and future.
by "Nielsen BookData"