Genetic toxicology : principles and methods
著者
書誌事項
Genetic toxicology : principles and methods
（Methods in molecular biology / John M. Walker, series editor, v. 817）（Springer protocols）
Humana Press, c2012
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
目次
1. The Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals
Philip Judson
2. Bacterial Mutagenicity Assays: Test Methods
David Gatehouse
3. The Mouse Lymphoma Assay
Melvyn Lloyd and Darren Kidd
4. Mammalian Cell HPRT Gene Mutation Assay: Test Methods
George E. Johnson
5. The In Vitro Mammalian Chromosome Aberration Test
Gill Clare
6. The Interpretation and Analysis of Cytogenetic Data
Natalie Danford
7. The In Vitro Micronucleus Assay
Ann T. Doherty
8. The In Vitro and In Vivo Comet Assays
Brian Burlinson
9. Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay
Jian Hong Wu and Nigel J. Jones
10. 32P-Postlabelling for the Sensitive Detection of DNA Adducts
Nigel J. Jones
11. Methods for the Detection of DNA Adducts
Karen Brown
12. The GADD45a-GFP GreenScreen HC Assay
Richard M. Walmsley and Matthew Tate
13. Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis
Shareen H. Doak and Zoulikha M. Zair
14. Cytogenetic In Vivo Assays in Somatic Cells
Ann T. Doherty, Adolph Baumgartner, and Diana Anderson
15. Cytogenetic Methods in Human Biomonitoring: Principles and Uses
Raluca A. Mateuca, Ilsa Decordier, and Micheline Kirsch-Volders
16. The Measurement of Induced Genetic Change in Mammalian Germ Cells
Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo
17. Transgenic Animal Mutation Models: A Review of the Models and How They Function
Steve Dean
18. Analysis of Genotoxicity Data in a Regulatory Context
Ian de G. Mitchell and David O.F. Skibinski
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