Cardiovascular biology : endothelial cell in health and hypertension
Author(s)
Bibliographic Information
Cardiovascular biology : endothelial cell in health and hypertension
（Biomedical and health research, v. 71）
IOS press, 2007-
- v. 1
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Note
Conference proceedings
Includes bibliographical references and index
Description and Table of Contents
Description
This volume has a focus on Vascular Endothelium, NO and Hypertension and is a continuum of the volumes on Mechanobiology of Cartilage and Chondrocyte. Indeed, vascular endothelial plays a significant role in regulating blood flow, and endothelial cells (EC) have highly active metabolic functions. They generate vasoactive mediators like prostacyclin, nitric oxide (NO) and endothelin (ET-1). Endothelial cells also synthesize various proteins like Von Willebrand's factor, growth factors and tissue plasminogen activators. They have also enzymes that inactivate bradykinin and convert angiotensin I into angiotension II (a vasopressor agent). In other respects, it is now well-known that mechanical forces and stretch can modulate EC functions by activating mechano-sensors, signaling pathways, genes and protein expressions. This mechanical approach leads to a better knowledge of vascular remodeling observed in many pathologies. These different aspects are all covered in this volume.
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