Applied biopharmaceutics & pharmacokinetics

著者

書誌事項

Applied biopharmaceutics & pharmacokinetics

Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu

McGraw-Hill Medical, c2012

6th ed

タイトル別名

Applied biopharmaceutics and pharmacokinetics

大学図書館所蔵 件 / 全4件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field's leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics.Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and eliminationCritically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalencyDesign and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parametersDetect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

目次

Preface Glossary 1. Intrtoduction to Biopharmaceutics and Pharmacokinetics 2. Mathematical Fundamentals in Pharmacokinetics 3. One-compartment Open Model: Intravenous Bolus Administration 5. Intravenous Infusion 6. Drug Elimination and clearance 7. Pharmacokinetics of Oral Absorption 8. Multiple-Dosage Regimens 9. Monlinear Pharmacokinetics 10. Physiologic Drub Distribution and Protein Binding 11. Drug Elimination and Hepatic Clearance 12. Pharmacogenetics 13. Physioloic Factors Related to Drug Absorption 14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance 15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence 16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy 17. Modified-Release Drug Products 18. Targeted Drug Delivery Symptoms and Biotechnological Products 19. Relationship Between Pharmacokeinetics and Pharmacodynamics 20. Application of Pharmacokinetics to Clinical Situations 21. Dose Adjustment in Renal and Hepatic Disease Appendix A Statistics Appendix B Applications of Computer in Pharmacokinetcs Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions Appendix D Guiding Prinicples for Human and Animal Research Appendix E Popular Drugs and Pharmacokinetic Parameters Index

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