Mitochondrial oxidative phosphorylation : nuclear-encoded genes, enzyme regulation, and pathophysiology
Author(s)
Bibliographic Information
Mitochondrial oxidative phosphorylation : nuclear-encoded genes, enzyme regulation, and pathophysiology
（Advances in experimental medicine and biology, v. 748）
Springer, c2012
Available at / 3 libraries
-
No Libraries matched.
- Remove all filters.
Note
Includes bibliographical references and index
Contents of Works
- Introduction to mitochondrial oxidative phosphorylation / Bernhard Kadenbach
- Mitochondrial dynamics: the intersection of form and function / Andrew Ferree and Orian Shirihai
- Biogenesis of mitochondrial proteins / Johannes M. Herrmann ... [et al.]
- Assembly factors of human mitochondrial respiratory chain complexes: physiology and pathophysiology / Daniele Ghezzi and Massimo Zeviani
- Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation / Giorgio Lenaz and Maria Luisa Genova
- Molecular mechanisms of superoxide production by the mitochondrial respiratory chain / Stefan Dröse and Ulrich Brandt
- Studies on the function and regulation of mitochondrial uncoupling proteins / Richard K. Porter
- Evolution of the couple cytochrome c and cytochrome c oxidase in primates / Denis Pierron ... [et al.]
- Reaction mechanism of mammalian mitochondrial cytochrome c oxidase / Shinya Yoshikawa, Kazumasa Muramoto and Kyoko Shinzawa-Itoh
- Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease / Maik Hüttemann ... [et al.]
- Individual biochemical behaviour versus biological robustness: spotlight on the regulation of cytochrome c oxidase / Rabia Ramzan ... [et al.]
- Bigenomic regulation of cytochrome c oxidase in neurons and the tight coupling between neuronal activity and energy metabolism / Margaret T. T. Wong-Riley
- Cytochrome c oxidase and its role in neurodegeneration and neuroprotection / Susanne Arnold
- The many clinical faces of cytochrome c oxidase deficiency / Salvatore DiMauro, Kurenai Tanji and Eric A. Schon
Description and Table of Contents
Description
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
Table of Contents
Preface.- Introduction.- Mitochondrial Dynamics: The Intersection of Form and Function.- Biogenesis of Mitochondrial Proteins.- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology.- Supramolecular Organization of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation.- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain.- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins.- Evolution of the Couple Cytochrome C and Cytochrome C Oxidase in Primates.- Reaction Mechanism of Mammalian Mitochondrial Cytochrome C Oxidase.- Phosphorylation of Mammalian Cytochrome C and Cytochrome C Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease.- Individual Biochemical Behavior Versus Biological Robustness: Spotlight on the Regulation of Cytochrome C Oxidase.- Bigenomic Regulation of Cytochrome C Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism.- Cytochrome C Oxidase and its Role in Neurodegeneration and Neuroprotection.- The Many Clinical Faces of Cytochrome C Oxidase Deficiency.- Index.
by "Nielsen BookData"
