Biotechnology of plasma proteins

書誌事項

Biotechnology of plasma proteins

Roger L. Lundblad

(Protein science series)

CRC Press Taylor & Francis Group, 2012, c2013

  • : hbk

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins. Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not published since 1975. Key Topics Protein Composition of Plasma Proteomic methods for plasma protein analysis Plasma protein biomarkers Validation of biomarkers Assays for plasma biomarkers Methods for the Analysis of Protein Products Assay development and validation Electrophoresis Chromatography Immunoassay Mass spectrometry Raman spectroscopy Plasma Fractionation: Historical and Modern Methods Development of Cohn alcohol fractionation Industrial methods Development of chromatographic methods Plasma Protein Products of Therapeutic Value Albumin Intravenous immunoglobulin Coagulation products Growth factors Wound management

目次

Blood, Plasma, Cells, and Other Biological Fluids. Plasma Fractionation and Plasma Protein Products. Methods for the Analysis of Plasma and Plasma Protein Fractions. Albumin. Plasma Immunoglobulins. Factor VIII and von Willebrand Factor. Plasma Proteinase Inhibitors. Vitamin K-Dependent Proteins. Miscellaneous Plasma Proteins.

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詳細情報

  • NII書誌ID(NCID)
    BB10690664
  • ISBN
    • 9781439850268
  • LCCN
    2012022036
  • 出版国コード
    us
  • タイトル言語コード
    eng
  • 本文言語コード
    eng
  • 出版地
    Boca Raton
  • ページ数/冊数
    xiii, 446 p.
  • 大きさ
    24 cm
  • 分類
  • 件名
  • 親書誌ID
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