Emerging Raman applications and techniques in biomedical and pharmaceutical fields

著者
    • Morris, Michael D.
    • Matousek, Pavel, Prof
書誌事項

Emerging Raman applications and techniques in biomedical and pharmaceutical fields

Pavel Matousek, Michael D. Morris (editors)

(Biological and medical physics, biomedical engineering)

Springer, c2010

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注記

Includes bibliographical references and index

On title page: "With 62 figures"

内容説明・目次

内容説明

In recent years, Raman spectroscopy has undergone a major transformation from a specialist laboratory technique to a practical analytical tool. This change was driven on several parallel fronts by dramatic advances in laser instrumentation, detectors, spectrometers, and optical ?lter technology. This resulted in the advent of a new generation of compact and robust Raman instruments with improved sensitivity and ?exibility. These devices could be operated for the ?rst time by non-specialists outside the laboratory envir- ment. Indeed, Raman spectroscopy is now found in the chemical and phar- ceutical industries for process control and has very recently been introduced into hospitals. Handheld instruments are used in forensic and other security applications and battery-operated versions for ?eld use are found in envir- mental and geological studies. Simultaneously, major advances have been seen in the development of powerful processing methods, some driven by the progress of related spect- scopic methods such as NIR absorption spectroscopy. Numerous chemometric packages are available for advanced analysis of data. These do not require specialist user knowledge (although caution is required in interpreting - sults) and provide further enhanced sensitivity and capability to the Raman technique. In this book we focus on two such major ?elds, biomedical and ph- maceutical. The book is aimed at life sciences and pharmaceutical re- erships. Accordingly, the chapter authors emphasize explanatory material with practical implications rather than focusing on mathematical detail.

目次

Lasers, Spectrographs, and Detectors.- Fiber-Optic Raman Probes for Biomedical and Pharmaceutical Applications.- Characterisation of Deep Layers of Tissue and Powders: Spatially Offset Raman and Transmission Raman Spectroscopy.- Applications of Raman and Surface-Enhanced Raman Scattering to the Analysis of Eukaryotic Samples.- Raman Imaging and Raman Mapping.- Coherent Raman Scattering Microscopy.- Raman Optical Activity of Biological Molecules.- Chemometric Methods for Biomedical Raman Spectroscopy and Imaging.- Discovery and Formulation.- Raman Spectroscopy: A Strategic Tool in the Process Analytical Technology Toolbox.- Emerging Dental Applications of Raman Spectroscopy.- Raman Spectroscopy of Ocular Tissue.- Raman Spectroscopy for Early Cancer Detection, Diagnosis and Elucidation of Disease-Specific Biochemical Changes.- Raman Spectroscopy of Bone and Cartilage.- Raman Microscopy and Imaging: Applications to Skin Pharmacology and Wound Healing.- Raman Spectroscopy of Blood and Urine Specimens.- Quantitative Raman Spectroscopy of Biomaterials for Arthroplastic Applications.- Raman Spectroscopy: A Tool for Tissue Engineering.- Applications of Raman Spectroscopy to Virology and Microbial Analysis.

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