Antibody mediated drug delivery systems : concepts, technology, and applications

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Antibody mediated drug delivery systems : concepts, technology, and applications

edited by Yashwant Pathak, Simon Benita

Wiley, c2012

  • : cloth

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内容説明・目次

内容説明

This book covers various aspects of antibody mediated drug delivery systems - theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

目次

CONTRIBUTORS xv PREFACE xix CHAPTER 1 ANTIBODY-MEDIATED DRUG DELIVERY SYSTEMS: GENERAL REVIEW AND APPLICATIONS Navdeep Kaur, Karthikeyan Subramani, and Yashwant Pathak 1 1 Historical Perspective 1 2 Antibodies 2 3 Antibody Mediation 3 4 Antibody-Mediated Drug Delivery Systems 4 5 Applications 6 6 Recent Trends 9 7 Future Trends 10 CHAPTER 2 IMMUNOLIPOSOMES FOR CARDIOVASCULAR TARGETING Tatyana Levchenko, William Hartner, and Vladimir P. Torchilin 13 1 Introduction 13 2 Immunoliposome Targeting to Pathological Regions of the Vessel Wall 14 3 Liposome Internalization by Endothelial Cells 15 4 Targeting of Atherosclerotic Lesions for Tomographic Imaging 17 5 Antibody-Mediated Liposomes for Diagnosis of Thrombosis 17 6 Thrombolytic Therapy with Immunoliposomes 18 7 Targeted Sealing of Cell Membrane Lesions: Preservation of Cell Viability 19 8 Accumulation of Liposomes and Immunoliposomes in the Ischemic Heart 21 9 Immunoliposomes as a Drug and Gene Delivery Vehicle to the Infarcted Heart 26 CHAPTER 3 ANTIBODY-MEDIATED DRUG DELIVERY SYSTEMS FOR BREAST CANCER THERAPEUTICS Leonor Munoz Alcivar and Yashwant Pathak 35 1 Introduction 35 2 Breast Cancer 35 3 Drug Delivery Systems 36 4 Monoclonal Antibodies 37 5 Human Epidermal Growth Factor Receptor 2 40 6 Antibody-Mediated Drug Delivery System 43 7 Targets for the Treatment of Breast Cancer 45 8 Breast Cancer Therapies 46 9 The Future of Breast Cancer Therapeutics 49 10 Other Treatment Strategies 50 11 Nanotechnology 51 12 Conclusions 52 CHAPTER 4 DEVELOPMENT OF IMMUNONCONJUGATES FOR IN VIVO DELIVERY: CANCER DIAGNOSIS, IMAGING, AND THERAPY Arutselvan Natarajan 57 1 Introduction 57 2 Immunoconjugates 61 3 Immunoconjugates in Cancer Therapy 62 4 Immunoconjugates for Imaging 69 5 Immunoconjugates in Diagnostic Applications 71 6 Immunoconjugates' Promising Future and Challenges 72 7 Summary 73 CHAPTER 5 MATHEMATICAL MODELS OF ANTI-TNF THERAPIES AND THEIR CORRELATION WITH TUBERCULOSIS Simeone Marino, Mohammad Fallahi-Sichani, Jennifer J. Linderman, and Denise E. Kirschner 83 1 Introduction 83 2 Tuberculosis, TNF, and Anti-TNF Drugs 84 3 Theoretical Models To Study TB Infection 88 4 Present and Future Work 96 CHAPTER 6 TARGETED NANOPARTICLES IN RADIOTHERAPY Misty Muscarella and Yashwant Pathak 105 1 Introduction 105 2 Nanoparticles 106 3 Radiotherapy 110 4 Nanoparticles in Radiotherapy 111 5 Current and Future Developments with Nanotechnology in Radiotherapy 123 6 Conclusions 124 CHAPTER 7 ELECTRICALLY-ENHANCED DELIVERY OF DRUGS AND CONJUGATES FOR CANCER TREATMENT Arutselvan Natarajan, Luca Campana, and Raji Sundararajan 129 1 Introduction 129 2 Electroporation Mechanisms to Permeabilize the Drugs and DNAs in Cells 130 3 Electroporation-Aided Drug Delivery for Preclinical Studies 133 4 EP applications for Human Patient Studies 136 5 Future Perspectives 138 6 Summary 139 CHAPTER 8 CHARACTERIZATION OF MONOCLONAL ANTIBODY VARIANTS AND GLYCOSYLATION Ting Zheng, Srinivasa Rao, Jeff Rohrer, and Chris Pohl 145 1 Characterization of Monoclonal Antibody Heterogeneity by HPLC Analysis 145 2 Analysis of Monoclonal Antibody Glycosylation 150 CHAPTER 9 ANTIBODY-MEDIATED DRUG DELIVERY SYSTEM FOR LYMPHATIC TARGETING TREATMENT Fang Wu, Hong Ding, and Zhirong Zhang 169 1 Introduction 169 2 Lymphatic Disorders and Their Normal Treatment 170 3 Antibody-Mediated Drug Delivery Systems for Lymphatic Targeting Treatment 172 4 Conclusions and Future Perspectives 183 CHAPTER 10 METHODS FOR NANOPARTICLE CONJUGATION TO MONOCLONAL ANTIBODIES Junling Li and Chin K. Ng 191 1 Introduction 191 2 Current Nanoparticle Systems used for Conjugation with mAbs 191 3 Conjugation Methods 192 4 Conclusions 202 CHAPTER 11 SINGLE-USE SYSTEMS IN ANIMAL CELL-BASED BIOPRODUCTION William G. Whitford 209 1 Introduction 209 2 Component Offerings 214 3 Characteristics of Single-Use Systems and Their Applications 218 CHAPTER 12 IMMUNOLIPOSOMES FOR SPECIFIC DRUG DELIVERY Manuela Calin 229 1 Introduction: Advances in Liposome Formulation 229 2 Design of Immunoliposomes for Site-Specific Drug Delivery 230 3 Cellular-Specific Targeting of Immunoliposomes 242 4 Cellular-Specific Internalization of Immunoliposomes 246 5 Immunoliposomes in Diagnosis and Therapy 247 6 Clinical Use of Immunoliposomes 251 7 Conclusions and Perspectives 252 CHAPTER 13 GENE THERAPY TARGETING KIDNEY DISEASES: ROUTES AND VEHICLES Yoshitaka Isaka, Yoshitsugu Takabatake, and Hiromi Rakugi 267 1 Introduction 267 2 Rationale for Successful Gene Targeting 268 3 Site-Specific Gene Delivery 268 4 Nuclear Import of Gene Material 270 5 Targeting the Glomerulus 270 6 Targeting the Tubule 272 7 Targeting the Interstitium 274 8 Targeting Muscle 274 9 Conclusions 275 CHAPTER 14 DETECTION OF ANTIBODIES TO POLY(ETHYLENE GLYCOL) POLYMERS USING DOUBLE-ANTIGEN-BRIDGING IMMUNOGENICITY ELISA Yijuan Liu, Helen Reidler, Jing Pan, David Milunic, Dujie Qin, Dave Chen, Yli Remo Vallejo, and Ray Yin 279 1 Introduction 279 2 Methods 280 3 Results 283 4 Discussion 286 CHAPTER 15 ANTIBODIES IN NANOMEDICINE AND MICROIMAGING METHODS Rakesh Sharma 291 1 Introduction: Antibody Molecules and Nanoparticles 291 2 Antibody-Based Nanoparticles in Microimaging 292 3 Troponin T: Newer Magnetic Immunoassay Method 317 4 Gold Nanoparticles as an Antigen Carrier and Adjuvant 330 5 Immunochemical Biosensors, Nanomedicine, and Disease 339 6 Future Directions and Conclusions 341 CHAPTER 16 METHODS FOR POLYMERIC NANOPARTICLE CONJUGATION TO MONOCLONAL ANTIBODIES Uyen Minh Le, Hieu Tran, and Yashwant Pathak 351 1 Introduction 351 2 Conjugation of mAb and Polyethylenimine Nanoparticles 353 3 Conjugation of mAb to Poly(Lactide-CO-Glycolide) Nanoparticles 357 4 Conjugation of mAb to Poly(Lactic Acid) and its Derivatives 359 5 Conjugation of mAb to Other Polymeric Nanoparticles 360 6 Summary 361 CHAPTER 17 PLANT-DERIVED ANTIBODIES FOR ACADEMIC, INDUSTRIAL, AND THERAPEUTIC APPLICATIONS Slavko Komarnytsky and Nikolai Borisjuk 365 1 Historical Perspective 365 2 Plant-Based Production of Recombinant Proteins 366 3 Expression in an Entire Plant Versus a Plant Organ 367 4 ER Targeting and Secretion of Recombinant Proteins 368 5 Expression in Seeds 370 6 Transient Expression 371 7 Glycosylation 373 8 Recent Examples of Plant-Derived Antibodies Effective in Mammalian Systems 375 9 Conclusions 376 CHAPTER 18 MONOCLONAL ANTIBODIES AS BIOPHARMACEUTICALS Girish J. Kotwal 383 1 Historical Perspective 383 2 Introduction 384 3 Structure and Types of mAbs 385 4 Mechanism of Action 385 5 FDA-approved mAb Biopharmaceuticals in Current Use 386 6 Future of Monoclonal Antibodies as Biopharmaceuticals 389 CHAPTER 19 PULMONARY TARGETING OF NANOPARTICLES AND MONOCLONAL ANTIBODIES Weiyuan Chang 391 1 Introduction 391 2 Attributes of mAbs as Therapeutics for Pulmonary Diseases 392 3 Antibody-Conjugated Nanoparticles for Lung Targeting 393 4 Monoclonal Antibodies in the Treatment of Asthma 394 5 Monoclonal Antibodies in the Treatment of COPD 398 6 Challenges in Pulmonary Disease 400 7 Conclusions 402 CHAPTER 20 ANTIBODY-MEDIATED ARTHRITIS AND NEW THERAPEUTIC AVENUES Kutty Selva Nandakumar 407 1 Autoantibodies in Rheumatoid Arthritis 407 2 Role of Cartilage Antigen-Specific Antibodies in Inducing Arthritis 408 3 Arthritis Mediation Through Antibodies Recognizing Citrullinated Antigens 413 4 Regulation at the Effector Level 414 5 Cartilage Damage Independent of Inflammatory Mediators 414 6 pathogenicity of GPI-Specific Antibodies 415 7 Therapeutic Cleavage of Arthritogenic Antibodies 415 8 Arthritis Attenuation Though Removal of Specific Sugars on IgG 417 CHAPTER 21 IMMUNONANOPARTICLES FOR NUCLEAR IMAGING AND RADIOTHERAPY Oren Giladi and Simon Benita 427 1 Radioisotopes and Radiopharmaceuticals 427 2 Radiolabeled Antibodies 432 3 Radiolabeled Nanoparticles 437 4 Future Perspectives and Conclusions 449 CHAPTER 22 MONOCLONAL ANTIBODIES IN THE TREATMENT OF ASTHMA Glenn J. Whelan 457 1 Introduction 457 2 IgE 458 3 TNF 460 4 IL-5 462 5 IL-9 464 6 IL-4 and IL-13 465 7 Targeting the T-cell 467 8 Conclusions 468 References 469 INDEX 473

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