Coarse-grained modelling of DNA and DNA self-assembly
著者
書誌事項
Coarse-grained modelling of DNA and DNA self-assembly
（Springer theses : recognizing outstanding Ph. D. research）
Springer, c2012
大学図書館所蔵 全1件
注記
"Doctral thesis accepted by the University of Oxford, UK" -- T.p
内容説明・目次
内容説明
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
目次
A Novel DNA Model.- Methods.- Finite Size Effects.- Structural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.
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