Animal models in diabetes research
著者
書誌事項
Animal models in diabetes research
（Methods in molecular biology / John M. Walker, series editor, 933）（Springer protocols）
Humana Press, c2012
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular Biology (TM) series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results.
Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.
目次
Part I: Rodent Models of Type 1 Diabetes
1. The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes
Kritika Kachapati, David Adams, Kyle Bednar, and William M. Ridgway
2. Assessment of Diabetic Nephropathy in the Akita Mouse
Jae-Hyung Chang and Susan B. Gurley
3. The BB Rat as a Model of Human Type 1 Diabetes
Rita Bortell and Chaoxing Yang
Part II: Rodent Models of Type 2 Diabetes
4. Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences
Darrell D. Belke and David L. Severson
5. Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome
Reinhart Kluge, Stephan Scherneck, Annette Schurmann, and Hans-Georg Joost
6. The TALLYHO Mouse as a Model of Human Type 2 Diabetes
Jung Han Kim and Arnold M. Saxton
7. Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)
Nurit Kaiser, Erol Cerasi, and Gil Leibowitz
8. Diabetes in Zucker Diabetic Fatty Rat
Masakazu Shiota and Richard L. Printz
9. The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes?
Bernard Portha, Marie-Helene Giroix, Cecile Tourrel-Cuzin, Herve Le-Stunff, and Jamileh Movassat
10. Experimentally Induced Rodent Models of Type 2 Diabetes
Md. Shahidul Islam and Rachel Dorothy Wilson
Part III: Other Species
11. Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates
Barbara C. Hansen
Part IV: General Methodology
12. Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets
Michael Willenborg, Kirstin Schumacher, and Ingo Rustenbeck
13. Determination of Beta-Cell Function: Ion Channel Function in Beta Cells
Martina Dufer
14. Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests
Francesco Beguinot and Cecilia Nigro
15. Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques
Masakazu Shiota
16. Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro
Henrike Sell, Jorgen Jensen, and Juergen Eckel
17. Beta-Cell Autoimmunity
Yannick F. Fuchs, Kerstin Adler, and Ezio Bonifacio
18. Positional Cloning of Diabetes Genes
Gudrun A. Brockmann and Christina Neuschl
19. Retinal Digest Preparation: A Method to Study Diabetic Retinopathy
Nadine Dietrich and Hans-Peter Hammes
20. Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration
Isabelle Houbracken, Iris Mathijs, and Luc Bouwens
21. Genetic Lineage Tracing of Beta Cell Neogenesis
Iris Mathijs, Isabelle Houbracken, and Luc Bouwens
Rita Bortell and Chaoxing Yang
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