Botulinum neurotoxins
Author(s)
Bibliographic Information
Botulinum neurotoxins
(Current topics in microbiology and immunology, 364)
Springer, c2013
Available at 6 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
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  United States of America
Note
Includes bibliographical references (p.315-317) and index
Description and Table of Contents
Description
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
Table of Contents
Preface.- Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. - Assembly and function of the Botulinum neurotoxin progenitor complex.- Uptake of botulinum neurotoxin in the intestine.- Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.- The elusive compass of clostridial neurotoxins: deciding when and where to go?.- Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons.- Clostridial neurotoxins light chains:devices for SNARE cleavage mediated blockade of neurotransmission.-Synaptic vesicle proteins - targets and routes for botulinum neurotoxins.- Persistence of Botulinum neurotoxin inactivation of nerve function.- Structure based drug discovery for Botulinum neurotoxins.- Complexity of botulinum neurotoxins: challenges for detection technology.- Progress in cell based assays for Botulinum neurotoxin detection.- Transforming the domain structure of botulinum neurotoxins into novel therapeutics.- Botulinum toxin: application, safety and limitations.- Subject index
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