Basic pharmacokinetics
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書誌事項
Basic pharmacokinetics
（CRC Press pharmacy education series）
CRC Press, c2012
2nd ed
- : hardback
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters.
After a basic introduction to pharmacokinetics and its related fields, the book examines:
Mathematical operations commonly used in pharmacokinetics
Drug distribution and clearance and how they affect the rate of drug elimination after a single dose
Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence
The steady-state concept during constant rate intravenous infusion and during multiple drug administration
Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion
Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling
Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics
Accompanying the book are downloadable resources with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
目次
Introduction to Pharmacokinetics. Review of Mathematical Fundamentals. Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Distribution. Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance. Drug Pharmacokinetics Following a Single IV Bolus Administration: The Rate of Drug Elimination. Drug Absorption Following Extravascular Administration: Biological, Physiological, and Pathological Considerations. Drug Absorption Following Extravascular Administration: Molecular and Physicochemical Considerations. Drug Absorption Following Extravascular Administration: Formulation Factors. Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption. Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption. Bioequivalence. Drug Pharmacokinetics during Constant Rate IV Infusion: The Steady-State Principle. Steady State during Multiple Drug Administration. Renal Drug Excretion. Metabolite Pharmacokinetics. Nonlinear Pharmacokinetics. Multicompartment Pharmacokinetic Models. Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusion. Pharmacokinetic-Pharmacodynamic Modeling. Noncompartmental Approach in Pharmacokinetic Data Analysis. Physiological Approach to Hepatic Clearance. Physiologically Based Pharmacokinetic Models. Therapeutic Drug Monitoring. Pharmacokinetics in Special Patient Populations. Pharmacokinetic Drug-Drug Interactions. Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability. Applications of Computers in Pharmacokinetics. The Companion CD. Solutions for the Practice Problems. Index.
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