Chemical biology : approaches to drug discovery and development to targeting disease

著者

    • Civjan, Natanya

書誌事項

Chemical biology : approaches to drug discovery and development to targeting disease

edited by Natanya Civjan

Wiley, c2012

  • : hardback

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

目次

Contributors xi PART I DRUG DISCOVERY AND DEVELOPMENT 1 1 The Role of Chemical Biology in Drug Discovery 3 Andrew J. Pope 2 Computational Approaches to Drug Discovery and Development 23 Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang 3 Design and Selection of Small Molecule Inhibitors 41 Jianwei Che, Yi Liu, and Nathanael S. Gray 4 Lead Optimization in Drug Discovery 65 Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J. Phillip Kennedy 5 Pharmacokinetics of Drug Candidates 83 Ronald E. White 6 ADME Properties of Drugs 101 Li Di and Edward H. Kerns 7 Drug Transport in Living Systems 115 Yael Elbaz and Shimon Schuldiner 8 Blood-Brain Barrier: Considerations in Drug Development and Delivery 133 David S. Miller and Brian T. Hawkins 9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147 Zhong Zuo and Vincent H. L. Lee 10 Pharmaceuticals: Natural Products and Natural Product Models 165 Sheo B. Singh PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203 11 The Role of Chemical Biology in Understanding and Treating Disease-Are Small Molecule "Correctors" the Way of the Future? 205 David Selwood 12 Anxiety Disorders 215 Miklos Toth 13 Chronic Obstructive Pulmonary Disease (COPD) 245 Peter J. Barnes 14 Depression 267 Glen B. Baker and Nicholas D. Mitchell 15 Osteoarthritis 293 Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis Berenbaum 16 Human Immunodeficiency Virus (HIV) 331 Joseph P. Vacca 17 Allergy and Asthma 341 Garry M. Walsh 18 Schizophrenia 357 Ferenc Martenyi 19 Protein Misfolding and Disease 379 Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth 20 Protein Trafficking Diseases 401 Heidi M. Sampson and David Y. Thomas 21 Metabolic Diseases 419 Cynthia M. Arbeeny 22 Mitochondrial Medicine 445 Richard J. T. Rodenburg and Jan A. M. Smeitink 23 Lysosomal Disorders 461 Doug A. Brooks and Maria Fuller Index 483

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