Reactions to psychotropic medication

著者

書誌事項

Reactions to psychotropic medication

Frank L. Tornatore ... [et al.]

Plenum Medical Book Co., c1987

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注記

Includes bibliographies and index

内容説明・目次

内容説明

After thousands of clinical trials, the efficacy of psychotropic drugs in the treatment of psychiatric disorders has become well established. However, the very success of these drugs has meant that many patients with chronic illnesses will receive them for a significant part of their lifetime. Side effects and other adverse reactions are an unfortunate but unavoidable component of successful pharmacotherapy. In- deed, the main emphasis in new drug development is often on the search for compounds that have fewer side effects, although no one has as yet found an effective drug without them. Therefore, it is important for clinicians to be aware of side effect reaction profiles, because they are often a major determining factor in the choice of therapy. After more than three decades of major breakthroughs in the development of psychotropic drugs, reactions to these medications are still frequently reported in the current liter- ature, and information about well-known reactions is con- stantly refined. This book is an attempt to systematically collect and organize this large body of data and present it in an easy-to-use form. All chapters follow the same reaction- oriented logic, and each important reaction is discussed using the same consistent subdivisions. The more clinically impor- tant reactions appear in the body of each chapter; the more unusual or rarely reported reactions are briefly characterized in the miscellaneous section at the end of each chapter.

目次

1 Reactions to Antipsychotics.- Autonomic Effects.- Anticholinergic Effects.- Temperature Regulation.- Cardiovascular Effects.- Electrocardiographic Effects.- Postural Hypotension.- Dermatological Effects.- Photosensitivity.- Pigmentation.- Skin Rashes.- Hematological Effects.- Agranulocytosis.- Other Blood Dyscrasias.- Hepatic Effects: Jaundice.- Metabolic and Endocrine Effects.- Amenorrhea and Galactorrhea.- Appearance of Medication in Breast Milk.- Gynecomastia.- Hyperglycemia.- Placental Transfer.- Sexual Dysfunction.- Weight Gain.- Breast Cancer.- Neuroleptic Malignant Syndrome.- Neurological Effects.- Anticholinergic Psychosis.- Extrapyramidal Symptoms.- Psychotic Exacerbation Induced by Neuroleptics.- Seizure Threshold Alteration.- Supersensitivity Psychosis.- Tardive Dyskinesia.- Ocular Abnormalities.- Corneal Lesions.- Epithelial Keratopathy.- Lesions of the Lens.- Retinitis Pigmentosa.- Pregnancy: Teratogenicity.- Renal Effects.- Sudden Death.- Syndrome of Inappropriate Antidiuretic Hormone.- Miscellaneous Effects.- 2 Reactions to Antidepressants: Tricyclic and Tetracyclic.- Anticholinergic Effects.- Blood Dyscrasias.- Cardiovascular Effects.- Conduction Delays.- Orthostatic Hypotension.- Dermatological Effects.- Endocrine Effects.- Galactorrhea and Amenorrhea.- Sexual Dysfunction.- Weight Gain.- Hepatic Effects.- Neurological Effects.- Agitation and Insomnia.- Central Nervous System Stimulation (Hypomania and Mania).- Electroencephalographic Changes.- Extrapyramidal Symptoms.- Seizure Threshold.- Teratogenic Effects.- Withdrawal Syndromes.- Worsening Schizophrenic Conditions.- Miscellaneous Effects.- 3 Reactions to Antidepressants: Monoamine Oxidase Inhibitors.- Cardiovascular Effects.- Hypertensive Crisis.- Orthostatic Hypotension.- Endocrine Effects.- Sexual Dysfunction.- Weight Gain.- Hepatic Effects.- Neurological Effects.- Hypomania.- Paresthesias.- Stimulant Effects.- Withdrawal Effects.- Miscellaneous Effects.- 4 Reactions to Lithium.- Dermatological Effects.- Cardiovascular Effects.- Gastrointestinal Effects.- Hematological Effects (Leukocytosis).- Renal Effects.- Diabetes Insipidus and Polyuria.- Structural Damage (Nephrotoxicity).- Teratogenic Effects.- Thyroid Effects (Hypothyroidism).- Tremor.- Weight Gain.- Withdrawal Effects.- Miscellaneous Effects.- 5 Reactions to Benzodiazepines.- Behavioral Effects.- Hostility.- Sedation.- Cardiovascular Effects.- Respiratory Effects.- Teratogenic Effects.- Withdrawal and Tolerance Effects.- Miscellaneous Effects.- 6 Reactions to Antiparkinson Agents.- Autonomic Effects.- Cardiovascular Effects.- Gastrointestinal Effects.- Ocular Effects.- Dermatological Effects.- Urological Effects.- Euphoric Effects.- Teratogenic Effects.- Miscellaneous Effects.- 7. Major Psychotropic Drug Interactions.- Antipsychotics.- Antidepressants.- Tricyclic and Tetracyclic.- Monoamine Oxidase Inhibitors.- Lithium.- Benzodiazepines.- Suggested Readings.

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